N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide

Research use only, not for human use.

N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide was reported as a STING inhbiitor.

N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide was reported as a STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease.

SN-001 targets the cyclic dinucleotide binding pocket of human STING.SN-001 (5-20 μM; 6 h) significantly impairs the induction of Ifnb mRNA, in a dose-dependent manner in L929 cells.SN-001 (10 μM; 3 h) inhibits cytosolic DNA-triggered STING signaling. Western Blot Analysis Cell Line:L929 cells Concentration:10 μM Incubation Time:3 h Result:Decreased cytosolic DNA-induced phosphorylation of STING, TBK1, IRF3, IκBα, and p65, as well as nuclear translocation of IRF3 and p65.

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Immunology/Inflammation

STING

STING

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727699-84-5

476.52

C26H21FN2O4S

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (524.64 mM)

COc(ccc(NC(c(cc1)ccc1-c1ccccc1)=O)c1)c1NS(c(cc1)ccc1F)(=O)=O

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(-20℃)

With Ice Pack

≥ 2 years