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SR-717

CAS No. 2375421-09-1

SR-717( —— )

Catalog No. M22380 CAS No. 2375421-09-1

SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 128 In Stock
2MG 43 In Stock
5MG 69 In Stock
10MG 117 In Stock
25MG 246 In Stock
50MG 388 In Stock
100MG 616 In Stock
200MG 861 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    SR-717
  • Note
    Research use only, not for human use.
  • Brief Description
    SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively.
  • Description
    SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Antitumor activity.SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner.
  • In Vitro
    ——
  • In Vivo
    Animal Model:WT or Stinggt/gt mice Dosage:30 mg/kg Administration:Intraperitoneally; once-per-day for 1 week Result:Maximally inhibited tumor growth.
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    STING
  • Recptor
    STING
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2375421-09-1
  • Formula Weight
    351.19
  • Molecular Formula
    C15H8F2LiN5O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:14.29 mg/mL (40.69 mM; Need ultrasonic)
  • SMILES
    [Li+].[O-]C(=O)c1cc(F)c(F)cc1NC(=O)c1ccc(nn1)-n1ccnc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chin E N , Yu C , Vartabedian V F , et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic[J]. ence, 2020, 369(6506):993-999.
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