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SR-717
CAS No. 2375421-09-1
SR-717( —— )
Catalog No. M22380 CAS No. 2375421-09-1
SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 128 | In Stock |
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| 2MG | 43 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 117 | In Stock |
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| 25MG | 246 | In Stock |
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| 50MG | 388 | In Stock |
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| 100MG | 616 | In Stock |
|
| 200MG | 861 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSR-717
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NoteResearch use only, not for human use.
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Brief DescriptionSR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively.
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DescriptionSR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Antitumor activity.SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner.
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In Vitro——
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In VivoAnimal Model:WT or Stinggt/gt mice Dosage:30 mg/kg Administration:Intraperitoneally; once-per-day for 1 week Result:Maximally inhibited tumor growth.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetSTING
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RecptorSTING
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Research Area——
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Indication——
Chemical Information
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CAS Number2375421-09-1
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Formula Weight351.19
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Molecular FormulaC15H8F2LiN5O3
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Purity>98% (HPLC)
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SolubilityDMSO:14.29 mg/mL (40.69 mM; Need ultrasonic)
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SMILES[Li+].[O-]C(=O)c1cc(F)c(F)cc1NC(=O)c1ccc(nn1)-n1ccnc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chin E N , Yu C , Vartabedian V F , et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic[J]. ence, 2020, 369(6506):993-999.
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