Jagged-1 188-204( —— )

Catalog No. M22523 CAS No. 219127-21-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Jagged-1 188-204
Note

Research use only, not for human use.
Brief Description

This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-αB activation.
Description

This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-αB activation.
In Vitro

Jagged-1 (188-204) is part of the DSL region, and highly conserved between human Jagged-1 and Jagged-2.
In Vivo

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Synonyms

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Pathway

Neuroscience
Target

Gamma-secretase
Recptor

Notch
Research Area

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Indication

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CAS Number

219127-21-6
Formula Weight

2107.4
Molecular Formula

C93H127N25O26S3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@H](Cc5ccc(O)cc5)NC(=O)[C@H](Cc6ccc(O)cc6)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CS
Chemical Name

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