Isocucurbitacin D

Research use only, not for human use.

Isocucurbitacin D showed a cytotoxic effect with disruption of target protein cofilin.

Isocucurbitacin D showed a cytotoxic effect with disruption of target protein cofilin. Isocucurbitacin D exhibited the highest activities of improved the LDL uptake rate.Isocucurbitacin D dose-dependently increased LDLR protein levels and decreased PCSK9 protein levels.

Isocucurbitacin D inhibits tumor cell growth with ED50s of 0.06, 0.2, 0.6, 0.8 and 1.2 μg/mL against SK-MEL-2, A549, XF498, HCT15 and SK-OV-3 cells, respectively. Cell Proliferation Assay Cell Line:MCF-7, MDA MB 231, A2780, A2780 CP, HepG2 and HCT-116 cells Concentration:0-100 μM Incubation Time:48 h Result:Inhibited cell proliferation with IC50s of 12.0, 30.7, 37.8, 47.9, >100 and >100 μM against MDA MB 231, HCT-116, HepG2, MCF-7, A2780 and A2780 CP, respectively.

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Others

Other Targets

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68422-20-8

516.7

C30H44O7

>98% (HPLC)

DMSO, Pyridine, Methanol, Ethanol, etc.

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(-20℃)

With Ice Pack

≥ 2 years