Protopine hydrochloride( —— )

Catalog No. M30941 CAS No. 6164-47-2

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Product Name

Protopine hydrochloride
Note

Research use only, not for human use.
Brief Description

Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracellular calcium concentration.
Description

Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracellular calcium concentration.Protopine seems to inhibit the heterotypic cell adhesion between MDA-MB-231 cells, and human umbilical vein endothelial cells by changing the expression of adhesive factors.
In Vitro

Western Blot Analysis Cell Line:HepG2, Huh7 Concentration:10, 20, 40 μM Incubation Time:24 h Result:Induced the cleavage of caspase-3 and caspase-9.Decreased Bcl-2 and Bcl-xl level.Induced the release of mitochondrial protein cytochrome c into the cytosol.
In Vivo

Animal Model:5-hydroxy-DL-tryptophan (5-HTP)-induced mice model Dosage:5, 10, 20 mg/kg Administration:i.p.Result:Increased the number of 5-HTP-induced head twitch response (HTR).Decreased the immobility time tested in the Tail suspension test (TST).
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