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Azaserine

CAS No. 115-02-6

Azaserine( CI-337 | O-Diazoacetyl-L-serine | P-165 )

Catalog No. M29606 CAS No. 115-02-6

Azaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces and functions as an inhibitor of glutamine amidotransferase.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Azaserine
  • Note
    Research use only, not for human use.
  • Brief Description
    Azaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces and functions as an inhibitor of glutamine amidotransferase.
  • Description
    Azaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces and functions as an inhibitor of glutamine amidotransferase.(In Vitro):Azaserine inhibits the hexosamine biosynthetic pathway, which shunts excessive intracellular glucose into the biosynthesis of UDP-N-acetylglucosamine and the formation of O-linked glycoproteins . Azaserine (25 μM) inhibits the glutamine-dependent amidotransferases involved in nucleotide biosynthesis, phosphoribosylformylglycinamidine synthetase, and glucosamine-6-phosphate isomerase.
  • In Vitro
    Azaserine (100 μg/mL; 6 h) causes some specific types of morphological changes of the sensitive organisms such as the characteristic elongation of Candida albicans cells.Azaserine (0-10 μM) inhibits the growth of E. coli strains with MIC values of 12.11, 51.9, 69.2 and 69.2 μg/mL for UTH 4, UTH 7036, UTH 7048 and UTH 7049.
  • In Vivo
    Azaserine (5 mg/kg; i.p. once or twice a week for 6 months) induces tumor in rats. Animal Model:Wistar rats Dosage:5 mg/kg Administration:Intraperitoneal injection; 5 mg/kg once or twice a week for 6 month Result:After 1 year most pancreases from treated rats were diffusely abnormal and contained many hyperplastic nodules and adenomas and more than rats one-quarter showed pancreatic adenocarcinoma.
  • Synonyms
    CI-337 | O-Diazoacetyl-L-serine | P-165
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    115-02-6
  • Formula Weight
    173.128
  • Molecular Formula
    C5H7N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 50 mg/mL (288.80 mM)
  • SMILES
    N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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