MMK 1( —— )

Catalog No. M30644 CAS No. 271246-66-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

MMK 1
Note

Research use only, not for human use.
Brief Description

Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proinflammatory cytokines IL-1β and IL-6. Also activates the neutrophil superoxide-generating NADPH-oxidase.
Description

Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proinflammatory cytokines IL-1β and IL-6. Also activates the neutrophil superoxide-generating NADPH-oxidase.
In Vitro

——
In Vivo

Animal Model:Four-week-old male ddY mice Dosage:10, 100, 1000 pmol/mouse Administration:ICV; 20 min before the testResult:Exerted an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse.
Synonyms

——
Pathway

GPCR/G Protein
Target

Calcium Channel
Recptor

——
Research Area

——
Indication

——

CAS Number

271246-66-3
Formula Weight

1610.97
Molecular Formula

C75H123N19O18S
Purity

>98% (HPLC)
Solubility

25% ethanol / water:0.50 mg/mL
SMILES

[H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(O)=O
Chemical Name

——