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MK-8998

CAS No. 953778-58-0

MK-8998( CX-8998 )

Catalog No. M16815 CAS No. 953778-58-0

MK-8998 (CX-8998) is a potent and selective antagonist of the T-type calcium channel for the treatment of schizophrenia.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MK-8998
  • Note
    Research use only, not for human use.
  • Brief Description
    MK-8998 (CX-8998) is a potent and selective antagonist of the T-type calcium channel for the treatment of schizophrenia.
  • Description
    MK-8998 (CX-8998) is a potent and selective antagonist of the T-type calcium channel for the treatment of schizophrenia.; does not block D2, 5HT2a, muscarinic, or histaminic receptors; has the potential for a substantially improved side effect profile compared with currently available atypical antipsychotics.Schizophrenia Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CX-8998
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    953778-58-0
  • Formula Weight
    380.4040296
  • Molecular Formula
    C20H23F3N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC(C)C1=CC=C(CC(N[C@H](C)C2=NC=C(OCC(F)(F)F)C=C2)=O)C=C1
  • Chemical Name
    Benzeneacetamide, 4-(1-methylethyl)-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyridinyl]ethyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Egan MF, et al. Hum Psychopharmacol. 2013 Mar;28(2):124-33.
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