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JTE-607 HCl
CAS No. 188791-09-5
JTE-607 HCl( JTE-607 | JTE 607 | JTE-607 HCl )
Catalog No. M23861 CAS No. 188791-09-5
JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 111 | In Stock |
|
| 5MG | 85 | In Stock |
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| 10MG | 154 | In Stock |
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| 25MG | 328 | In Stock |
|
| 50MG | 508 | In Stock |
|
| 100MG | 731 | In Stock |
|
| 200MG | 1004 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJTE-607 HCl
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NoteResearch use only, not for human use.
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Brief DescriptionJTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
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DescriptionJTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
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In VitroRT-PCR Cell Line:human peripheral blood mononuclear cells (PBMCs)Concentration:100 nM Incubation Time:20 hours Result:Reduced the increase in the level of mRNAs of TNF-α, IL-1b, IL-6 and IL-8.
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In VivoAnimal Model:Male C57BL/6 mice (5 to 6 weeks old) are sensitized by injecting Corynebacterium parvumDosage:0.3, 1, 3, 10 mg/kg Administration:Administered intravenously 10 min before the LPS challenge. Result:Showed dose dependent inhibition of the mortality at 0.3 to 10 mg/kg and significant effect at 3 and 10 mg/kg.
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SynonymsJTE-607 | JTE 607 | JTE-607 HCl
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PathwayProteasome/Ubiquitin
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TargetCysteine Protease
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RecptorCystine
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Research Area——
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Indication——
Chemical Information
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CAS Number188791-09-5
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Formula Weight525.3
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Molecular FormulaC22H29Cl4N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (418.51 mM)
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SMILESO=C(N(CC)C1=CC=CC=C1)C2=CC(Cl)=C(OCCN3CCN(C)CC3)C(Cl)=C2O.[H]Cl.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Borozdenkova S, Mant TG, Allen E, Pu K, Hoshino S, Jurcevic S. Effects of a cytokine inhibitor, JTE-607, on the response to endotoxin in healthy human volunteers. Int Immunopharmacol. 2011 Nov;11(11):1837-43. doi: 10.1016/j.intimp.2011.07.013.
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