OBX02-011( —— )

Catalog No. M28999 CAS No. 2349336-18-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

OBX02-011
Note

Research use only, not for human use.
Brief Description

OBX02-011 is an effective and reversible inhibitor of EGFR tyrosine kinase with IC50s of 0.134 and 2.09 nM for triple mutants Del19/T790M/C797S and L858R/T790M/C797S.
Description

OBX02-011 is an effective and reversible inhibitor of EGFR tyrosine kinase with IC50s of 0.134 and 2.09 nM for triple mutants Del19/T790M/C797S and L858R/T790M/C797S.(In Vitro):OBX02-011 shows broad activity at low nanomolar concentrations against mutant EGFRs. OBX02-011 occupies the ATP-binding site in a similar manner to WZ-4002.(In Vivo):In transgenic mouse models, OBX02-011 (25 mg/kg, i. p.) effectively inhibits tumor growth and EGFR activity and leads to enhanced survival.
In Vitro

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In Vivo

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Synonyms

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Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR
Research Area

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Indication

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CAS Number

2349336-18-9
Formula Weight

615.19
Molecular Formula

C29H39ClN8O3S
Purity

>98% (HPLC)
Solubility

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SMILES

O=S(=O)(N(C=1C=CC=CC1NC2=NC(=NC=C2Cl)NC3=CC=C(C=C3OC)N4CCC(N5CCN(C)CC5)CC4)C)C
Chemical Name

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