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DB818
CAS No. 790241-43-9
DB818( —— )
Catalog No. M28983 CAS No. 790241-43-9
DB818 is a synthetic Homeobox A9 (HOXA9) inhibitor and can be used for research on the treatment of acute myeloid leukaemia associated with HOXA9 overexpression.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 337 | Get Quote |
|
| 10MG | 503 | Get Quote |
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| 25MG | 861 | Get Quote |
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| 50MG | 1296 | Get Quote |
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| 100MG | 1962 | Get Quote |
|
| 200MG | 2988 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameDB818
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NoteResearch use only, not for human use.
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Brief DescriptionDB818 is a synthetic Homeobox A9 (HOXA9) inhibitor and can be used for research on the treatment of acute myeloid leukaemia associated with HOXA9 overexpression.
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DescriptionDB818 is a synthetic Homeobox A9 (HOXA9) inhibitor and can be used for research on the treatment of acute myeloid leukaemia associated with HOXA9 overexpression.(In Vitro):In the three AML cell lines, DB818 suppressed growth, induced apoptosis, and down-regulated the expression of HOXA9 transcriptional target genes: MYB proto-oncogene, transcription factor (MYB), MYC proto-oncogene, bHLH transcription factor (MYC), and BCL2 apoptosis regulator (BCL2), while up-regulating that of Fos proto-oncogene, AP-1 transcription factor subunit (FOS). HOXA9 knockdown showed similar effects, except for MYC expression, which differed between DB818-treated and HOXA9-deficient OCI/AML3 cells, suggesting an off-target effect of DB818.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number790241-43-9
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Formula Weight360.44
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Molecular FormulaC19H16N6S
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Purity>98% (HPLC)
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Solubility——
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SMILESNC(c(cc1)cc2c1nc(-c1ccc(-c3ccc(/C=N\N)cc3)s1)[nH]2)=N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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H-Abu-OH
L-alpha-Aminobutyric acid also known as (S)-2-aminobutanoic acid homoalanine 2-AABA ethylglycine or L-butyrine is a member of the class of compounds known as L-alpha-amino acids. L-alpha-Aminobutyric acid is a non-proteogenic amino acid that can be found in the human kidney in liver tissues and in most biofluids or excreta (e.g. feces breast milk urine and blood).
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AdTx1
Selective, high affinity, non-competitive α1A adrenoceptor antagonist (Ki = 0.35 nM). Exhibits no significant activity against a range of other GPCRs, including α2A, β1 and β2 adrenoceptors. Antagonizes effects of phenylephrine on isolated rabbit prostate muscle in vitro and on intra-urethral pressure in rats.
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SGN-2FF
SGN-2FF is an oral fucosyltransferase inhibitor with antitumor activity.
