STING activator Compound 53( 1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide )

Catalog No. M28935 CAS No. 2259624-71-8

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Product Name

STING activator Compound 53
Note

Research use only, not for human use.
Brief Description

STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.
Description

STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.
In Vitro

STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells.STING agonist-12 is not active at mouse STING.
In Vivo

STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life. Animal Model:Balb/c mice (n=3) Dosage:5 or 10 mpk Administration:Lateral tail vein or oral gavage (Pharmacokinetic Analysis)Result:Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse.
Synonyms

1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide
Pathway

Immunology/Inflammation
Target

STING
Recptor

Autophagy
Research Area

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Indication

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1.Gao Y, et al. Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy. Cell Death Dis. 2016 Aug 11;7(8):e2330.

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