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STING activator Compound 53
CAS No. 2259624-71-8
STING activator Compound 53( 1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide )
Catalog No. M28935 CAS No. 2259624-71-8
STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 84 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 120 | In Stock |
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| 25MG | 250 | In Stock |
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| 50MG | 392 | In Stock |
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| 100MG | 584 | In Stock |
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| 200MG | 830 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSTING activator Compound 53
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NoteResearch use only, not for human use.
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Brief DescriptionSTING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.
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DescriptionSTING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.
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In VitroSTING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells.STING agonist-12 is not active at mouse STING.
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In VivoSTING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life. Animal Model:Balb/c mice (n=3) Dosage:5 or 10 mpk Administration:Lateral tail vein or oral gavage (Pharmacokinetic Analysis)Result:Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse.
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Synonyms1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide
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PathwayImmunology/Inflammation
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TargetSTING
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RecptorAutophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number2259624-71-8
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Formula Weight490.88
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Molecular FormulaC25H19ClF4N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (509.29 mM)
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SMILESCC(C)(c(ccc(C(NCc(c(F)cc(F)c1)c1F)=O)c1)c1N1Cc(c(F)ccc2)c2Cl)C1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Gao Y, et al. Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy. Cell Death Dis. 2016 Aug 11;7(8):e2330.
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