Cridanimod

CAS No. 38609-97-1

Cridanimod( 10-carboxymethyl-9-acridanone | 10-CMA | XBIO-101 )

Catalog No. M14331 CAS No. 38609-97-1

Cridanimod (10-carboxymethyl-9-acridanone, 10-CMA, XBIO-101) is a potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
25MG 40 In Stock
50MG 60 In Stock
100MG 91 In Stock
200MG Get Quote In Stock
500MG 269 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Cridanimod
  • Note
    Research use only, not for human use.
  • Brief Description
    Cridanimod (10-carboxymethyl-9-acridanone, 10-CMA, XBIO-101) is a potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.
  • Description
    Cridanimod (10-carboxymethyl-9-acridanone, 10-CMA, XBIO-101) is a potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route; displays extraordinary activity in phosphorylating IRF3 in the murine system; also increases progesterone receptor (PrR) expression in endometrial tissue.Ovarian Cancer Phase 2 Clinical(In Vivo):Cridanimod (IM; 1-6 mg; twice a week) has a significantly longer survival time. Cridanimod significant increases in IFNα and -β in cridanimod-treated mice in a dose-dependent manner.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Athymic mice with hec50co cells Dosage:1, 3, 6 mg Administration:IM; twice a week Result:Had a significantly longer survival time.
  • Synonyms
    10-carboxymethyl-9-acridanone | 10-CMA | XBIO-101
  • Pathway
    Immunology/Inflammation
  • Target
    STING
  • Recptor
    mSTING
  • Research Area
    Cancer
  • Indication
    Ovarian Cancer

Chemical Information

  • CAS Number
    38609-97-1
  • Formula Weight
    253.25
  • Molecular Formula
    C15H11NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 25 mg/mL, 98.7 mM ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3N2CC(=O)O
  • Chemical Name
    2-(9-oxoacridin-10-yl)acetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cavlar T, et al. EMBO J. 2013 May 15;32(10):1440-50. 2. Zhang H, et al. Sci Rep. 2015 Dec 16;5:18035.
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