Cridanimod( 10-carboxymethyl-9-acridanone | 10-CMA | XBIO-101 )

Catalog No. M14331 CAS No. 38609-97-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Cridanimod
Note

Research use only, not for human use.
Brief Description

Cridanimod (10-carboxymethyl-9-acridanone, 10-CMA, XBIO-101) is a potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.
Description

Cridanimod (10-carboxymethyl-9-acridanone, 10-CMA, XBIO-101) is a potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route; displays extraordinary activity in phosphorylating IRF3 in the murine system; also increases progesterone receptor (PrR) expression in endometrial tissue.Ovarian Cancer Phase 2 Clinical(In Vivo):Cridanimod (IM; 1-6 mg; twice a week) has a significantly longer survival time. Cridanimod significant increases in IFNα and -β in cridanimod-treated mice in a dose-dependent manner.
In Vitro

——
In Vivo

Animal Model:Athymic mice with hec50co cells Dosage:1, 3, 6 mg Administration:IM; twice a week Result:Had a significantly longer survival time.
Synonyms

10-carboxymethyl-9-acridanone | 10-CMA | XBIO-101
Pathway

Immunology/Inflammation
Target

STING
Recptor

mSTING
Research Area

Cancer
Indication

Ovarian Cancer

CAS Number

38609-97-1
Formula Weight

253.25
Molecular Formula

C15H11NO3
Purity

>98% (HPLC)
Solubility

DMSO: 25 mg/mL, 98.7 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3N2CC(=O)O
Chemical Name

2-(9-oxoacridin-10-yl)acetic acid

1. Cavlar T, et al. EMBO J. 2013 May 15;32(10):1440-50. 2. Zhang H, et al. Sci Rep. 2015 Dec 16;5:18035.

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