ML339( —— )

Catalog No. M28860 CAS No. 2579689-83-9

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Datasheet

HNMR

HPLC

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Product Name

ML339
Note

Research use only, not for human use.
Brief Description

ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
Description

ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.(In Vitro):The murine assay was validated using anti-mCXCR16 as an antagonist positive control tested in the presence of an EC80 concentration of mCXCL16 (IC50 = 1.5 nM; % response = 100%). Probe ML339 was shown to be 100-fold less active at the murine CXCR6 receptor using the DiscoveRx β-arrestin cell-based assay format.
In Vitro

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In Vivo

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Synonyms

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Pathway

Autophagy
Target

CXCR
Recptor

CDK9
Research Area

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Indication

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CAS Number

2579689-83-9
Formula Weight

502
Molecular Formula

C26H32ClN3O5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 75 mg/mL (149.40 mM)
SMILES

O=C(NC1=CC=CC=C1Cl)CN2[C@H]3C[C@@H](NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)C[C@@H]2CCC3
Chemical Name

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1.Bian J, et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.

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