CHIR98014( CHIR98014 | CHIR-98014 | CHIR 98014 )

Catalog No. M17541 CAS No. 556813-39-9

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Product Name

CHIR98014
Note

Research use only, not for human use.
Brief Description

CHIR 98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
Description

CHIR98014, also known as CT-98024, is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50 = 0.65 and 0.58 nM, respectively). It is inactive against a series of other serine/threonine or tyrosine kinases. Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50 = 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals. CHIR98014 also reduces tau phosphorylation in rat brains and supports Wnt signaling during osteogenesis.
In Vitro

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In Vivo

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Synonyms

CHIR98014 | CHIR-98014 | CHIR 98014
Pathway

Autophagy
Target

CXCR
Recptor

GSK-3α/β| p70 S6K
Research Area

Cancer
Indication

——

CAS Number

556813-39-9
Formula Weight

486.31
Molecular Formula

C20H17Cl2N9O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (257.04 mM)
SMILES

c1cc(c(cc1Cl)Cl)c1nc(ncc1c1[nH]ccn1)NCCNc1nc(c(cc1)[N+](=O)[O-])N
Chemical Name

N2-(2-((4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)-5-nitropyridine-2,6-diamine

1. Ring DB,et al. Diabetes. 2003, 52(3), 588-595.

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