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ZZW-115 hydrochloride
CAS No. 10122-45-9
ZZW-115 hydrochloride( —— )
Catalog No. M28706 CAS No. 10122-45-9
ZZW-115 hydrochloride inhibits the activity of NUPR1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 178 | In Stock |
|
| 10MG | 282 | In Stock |
|
| 25MG | 480 | In Stock |
|
| 50MG | 691 | In Stock |
|
| 100MG | 972 | In Stock |
|
| 500MG | 1944 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameZZW-115 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionZZW-115 hydrochloride inhibits the activity of NUPR1.
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DescriptionZZW-115 hydrochloride inhibits the activity of NUPR1.
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In VitroCell Viability Assay Cell Line:ANOR cells, MiaPaCa-2, 02-063, 01008, LIPC, 02136, HN01,01046, AOIPC, Foie8b, HN14 cells Concentration:0.1- 33 μM Incubation Time:72 hours Result:Was efficient in killing cancer cells, with an IC50 in the range of 0.84 μM (ANOR) to 4.93 μM (HN14).Cell Proliferation Assay Cell Line:U87, A375, U2OS, SaOS-2, HT29, SK-CO-1, LS174T, H1299 and H358, HepG2, PC3, THP-1, Daudi, Jurkat and MDA-MB-231 cells Concentration:0-100 μM Incubation Time:24 or 72 hours Result:Was efficient to kill these tumor cells with an IC50 in the range of 0.42 μM (Hep2G cells) to 7.75 μM (SaOS-2 cells).
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In VivoAnimal Model:NMRI-Foxn1nu/Foxn1nu mice (nude mice) xenografted with MiaPaCa-2 cells Dosage:5, 2.5, 1.0, or 0.5 mg/kg Administration:Injection; daily for 30 days Result:When the mice were injected with 5 mg/kg ZZW-115 hydrochloride, the tumors stopped growing a few days after treatment and their size decreased progressively, almost disappearing at the end of the treatment.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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Recptor5-HT1F
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Research Area——
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Indication——
Chemical Information
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CAS Number10122-45-9
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Formula Weight573.97
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Molecular FormulaC24H34Cl3F3N4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (145.18 mM)
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SMILESFC(F)(F)C1=CC=C(SC2=C3C=CC=C2)C(N3CCCN4CCN(CC4)CCN(C)C)=C1.[H]Cl.[H]Cl.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Michael Edward Flaugh, et al. 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists. US 5708187 A.
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