β-Elemene

Research use only, not for human use.

β-Elemene is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.β-Elemene significantly inhibited the metastatic capacity of MDR gastric cells in vivo and in vitro. Mechanistically, β-Elemene regulated MMP-2/9 expression and reversed epithelial-mesenchymal transition.

β-Elemene is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.β-Elemene significantly inhibited the metastatic capacity of MDR gastric cells in vivo and in vitro. Mechanistically, β-Elemene regulated MMP-2/9 expression and reversed epithelial-mesenchymal transition. β-Elemene upregulated Cbl-b expression, resulting in inhibition of the EGFR-ERK/AKT pathways, which regulate MMP-2/9. β-Elemene upregulated Cbl-b by inhibiting miR-1323 expression. Numbers of metastatic tumor nodules were significantly decreased in the lungs of nude mice after β-Elemene treatment. β-Elemene inhibits the metastasis of MDR gastric cancer cells by modulating the miR-1323/Cbl-b/EGFR signaling axis.

Cell Viability Assay Cell Line:T24, 5637, TCCSUP, J82, UM-UC-3, RT4 and SW780 cells Concentration:0, 6.25, 12.5, 25, 50, 100, 150 and 200 μg/ml Incubation Time:24 hours Result:Inhibited the proliferation of RT4, SW780, J82, UMUC-3, TCCSUP, 5637 and T24 human bladder cancer cells and SV-HUC-1 human urothelial cells.?Cell Cycle AnalysisCell Line:T24 and 5637 cells Concentration:0, 25, 50 and 75 μg/ml Incubation Time:24 hours Result:Induced the percentage of cells in the S-phase?as a dose-dependent manner.Western Blot AnalysisCell Line:T24 cells Concentration:50 μg/ml Incubation Time:24 hours Result:Downregulated p-STAT3 and cell cycle-related proteins.

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(-)-β-Elemene,Levo-β-elemene

Apoptosis

Apoptosis

Apoptosis

cancer

Anaplastic Oligoastrocytoma|Anaplastic Astrocytoma|Glioblastoma

515-13-9

204.35

C15H24

>98% (HPLC)

DMSO:50 mg/mL (244.68 mM; Need ultrasonic)

CC([C@H]1[C@@](C)(CC[C@@H](C(C)=C)C1)C=C)=C

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(-20℃)

With Ice Pack

≥ 2 years