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Mesdopetam hemitartrate

CAS No. 2562346-14-7

Mesdopetam hemitartrate( 1-?Propanamine, N-?[2-?[3-?fluoro-?5-?(methylsulfonyl)?phenoxy]?ethyl]?-?, (2R,?3R)?-?2,?3-?dihydroxybutanedioat?e (2:1) | IRL790 hemitartrate )

Catalog No. M28670 CAS No. 2562346-14-7

Mesdopetam hemitartrate is an antagonist of dopamine D3 receptor (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Mesdopetam hemitartrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Mesdopetam hemitartrate is an antagonist of dopamine D3 receptor (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor).
  • Description
    Mesdopetam hemitartrate is an antagonist of dopamine D3 receptor (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor). It has psychomotor stabilizing properties.
  • In Vitro
    ——
  • In Vivo
    Mesdopetam (IRL790) (3.7, 11, 33, or 100 μmol/kg; s.c.) hemitartrate dose-dependently inhibits the behavioral activation following pretreatment with D-amphetamine or MK-80. Animal Model:Male Sprague-Dawley ratsDosage:3.7, 11, 33, or 100 μmol/kg (synthesized in-house as HCl salt, was dissolved in physiologic saline (0.9% w/v NaCl) Administration:s.c. was administered subcutaneously 4 min before the start of recording Result:Dose-dependently inhibited the behavioral activation following pretreatment with D-amphetamine or MK-801.
  • Synonyms
    1-?Propanamine, N-?[2-?[3-?fluoro-?5-?(methylsulfonyl)?phenoxy]?ethyl]?-?, (2R,?3R)?-?2,?3-?dihydroxybutanedioat?e (2:1) | IRL790 hemitartrate
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    p38α
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2562346-14-7
  • Formula Weight
    700.77
  • Molecular Formula
    C28H42F2N2O12S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 100 mg/mL (142.70 mM)
  • SMILES
    CCCNCCOC1=CC(S(=O)(C)=O)=CC(F)=C1.CCCNCCOC2=CC(S(=O)(C)=O)=CC(F)=C2.O=C(O)[C@H](O)[C@@H](O)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Baker W, et al. Monophosphates as mutual prodrugs of anti-inflammatory signal transduction modulators (aistm's) and β-agonists for the treatment of pulmonary inflammation and bronchoconstriction. WO 2008076265 A1.
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