Cart
sales@molnova.com
FAUC-365
CAS No. 474432-66-1
FAUC-365( FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide )
Catalog No. M27448 CAS No. 474432-66-1
FAUC-365 is a D3 dopamine receptor agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 119 | In Stock |
|
| 5MG | 107 | In Stock |
|
| 10MG | 163 | In Stock |
|
| 25MG | 322 | In Stock |
|
| 50MG | 500 | In Stock |
|
| 100MG | 724 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1507 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameFAUC-365
-
NoteResearch use only, not for human use.
-
Brief DescriptionFAUC-365 is a D3 dopamine receptor agonist.
-
DescriptionFAUC-365 is a D3 dopamine receptor agonist.(In Vitro):As a dichloro derivative, FAUC-365 revealed D3 affinities that were comparable to its methoxy-substituted analogs, however, the selectivities of FAUC-365 against 5HT-1A, 5-HT2, and R1 were substantially higher, which was demonstrated by the extraordinary selectivity ratios of 17600, 7200, 5200, and 680 over D1, D2long, D2short, and D4, respectively, were determined for FAUC-365 with Ki of 0.50 nM. In addition, the benzothiophene analog FAUC 346 and its oxa analog showed partial agonist character with EC50 values at 0.36 and 1.5 nM, respectively .
-
In Vitro——
-
In Vivo——
-
SynonymsFAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide
-
PathwayGPCR/G Protein
-
TargetDopamine Receptor
-
RecptorLOXL2|LOXL3
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number474432-66-1
-
Formula Weight462.43
-
Molecular FormulaC23H25Cl2N3OS
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 33.33 mg/mL (72.07 mM)
-
SMILESClc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4s3)CC2)c1Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Findlay AD,et al. Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3. J Med Chem. 2019 Nov 14;62(21):9874-9889.
molnova catalog
related products
-
Nomifensine
Nomifensine is a norepinephrine-dopamine reuptake inhibitor that prevents dopamine reuptake into synaptosomes.
-
Sulpiride
Sulpiride is a D2 receptor a antagonist, an atypical antipsychotic drug of the benzamide class.
-
LE 300
LE 300 represents a structurally novel type of antagonists acting preferentially at the dopamine D(1)/D(5)receptors and the serotonin 5-HT(2A)receptor.
