FAUC-365

Research use only, not for human use.

FAUC-365 is a D3 dopamine receptor agonist.

FAUC-365 is a D3 dopamine receptor agonist.(In Vitro):As a dichloro derivative, FAUC-365 revealed D3 affinities that were comparable to its methoxy-substituted analogs, however, the selectivities of FAUC-365 against 5HT-1A, 5-HT2, and R1 were substantially higher, which was demonstrated by the extraordinary selectivity ratios of 17600, 7200, 5200, and 680 over D1, D2long, D2short, and D4, respectively, were determined for FAUC-365 with Ki of 0.50 nM. In addition, the benzothiophene analog FAUC 346 and its oxa analog showed partial agonist character with EC50 values at 0.36 and 1.5 nM, respectively .

——

——

FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide

GPCR/G Protein

Dopamine Receptor

LOXL2|LOXL3

——

——

474432-66-1

462.43

C23H25Cl2N3OS

>98% (HPLC)

In Vitro:?DMSO : 33.33 mg/mL (72.07 mM)

Clc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4s3)CC2)c1Cl

——

(-20℃)

With Ice Pack

≥ 2 years