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NMI 8739
CAS No. 129024-87-9
NMI 8739( Dha-DA conjugate | n-docosahexaenoyl dopamine )
Catalog No. M26172 CAS No. 129024-87-9
NMI 8739 is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 75 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 117 | In Stock |
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| 25MG | 206 | In Stock |
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| 50MG | 296 | In Stock |
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| 100MG | 439 | In Stock |
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| 200MG | 638 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNMI 8739
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NoteResearch use only, not for human use.
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Brief DescriptionNMI 8739 is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release.
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DescriptionNMI 8739 is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release.(In Vitro):NMI 8739 (2 μM) significantly inhibits IL-6 and CCL-20 release up to 49% and 37%, respectivel. NMI 8739 suppresses the production of PGE2 in a concentration-dependent manner with 25.3%, 75% reduction at doses of 100 nM and 1 μM, respectively.
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In VitroNMI 8739 is a dopamine D2 autoreceptor agonist, which is an amine conjugate of the DHA carrier and the neurotransmitter dopamine. NMI 8739 reduces nitric oxide (NO) production in LPS-stimulated RAW264.7 Macrophages. NMI 8739 elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 Release in RAW264.7 macrophages after LPS-stimulation. Production of PGE2 is concentration-dependently suppressed with a reduction of 25.3% at 100 nM NMI 8739 and a 75% reduction for 1 μM NMI 8739. 2 μM NMI 8739 significantly inhibits IL-6 and CCL-20 release up to 49% and 37%, respectively.
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In Vivo——
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SynonymsDha-DA conjugate | n-docosahexaenoyl dopamine
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number129024-87-9
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Formula Weight463.662
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Molecular FormulaC30H41NO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?Ethanol : 100 mg/mL (215.68 m)
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SMILESCC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(=O)NCCc1ccc(O)c(O)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jeon JS, Kang HM, Park SY, Choi YW. Comparative study of the photo?protective and anti?melanogenic properties of gomisin D, J and O. Mol Med Rep. 2022 Jan;25(1):8.
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