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NMI 8739

CAS No. 129024-87-9

NMI 8739( Dha-DA conjugate | n-docosahexaenoyl dopamine )

Catalog No. M26172 CAS No. 129024-87-9

NMI 8739 is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    NMI 8739
  • Note
    Research use only, not for human use.
  • Brief Description
    NMI 8739 is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release.
  • Description
    NMI 8739 is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release.(In Vitro):NMI 8739 (2 μM) significantly inhibits IL-6 and CCL-20 release up to 49% and 37%, respectivel. NMI 8739 suppresses the production of PGE2 in a concentration-dependent manner with 25.3%, 75% reduction at doses of 100 nM and 1 μM, respectively.
  • In Vitro
    NMI 8739 is a dopamine D2 autoreceptor agonist, which is an amine conjugate of the DHA carrier and the neurotransmitter dopamine. NMI 8739 reduces nitric oxide (NO) production in LPS-stimulated RAW264.7 Macrophages. NMI 8739 elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 Release in RAW264.7 macrophages after LPS-stimulation. Production of PGE2 is concentration-dependently suppressed with a reduction of 25.3% at 100 nM NMI 8739 and a 75% reduction for 1 μM NMI 8739. 2 μM NMI 8739 significantly inhibits IL-6 and CCL-20 release up to 49% and 37%, respectively.
  • In Vivo
    ——
  • Synonyms
    Dha-DA conjugate | n-docosahexaenoyl dopamine
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    129024-87-9
  • Formula Weight
    463.662
  • Molecular Formula
    C30H41NO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?Ethanol : 100 mg/mL (215.68 m)
  • SMILES
    CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(=O)NCCc1ccc(O)c(O)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jeon JS, Kang HM, Park SY, Choi YW. Comparative study of the photo?protective and anti?melanogenic properties of gomisin D, J and O. Mol Med Rep. 2022 Jan;25(1):8.
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