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PLN-1474
CAS No. 2408065-32-5
PLN-1474( PLN1474 )
Catalog No. M28546 CAS No. 2408065-32-5
PLN-1474 is a potent αVβ1 inibitor with IC50 < 50nM (WO2021127483, compound 1)
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 120 | In Stock |
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| 5MG | 107 | In Stock |
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| 10MG | 180 | In Stock |
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| 25MG | 306 | In Stock |
|
| 50MG | 431 | In Stock |
|
| 100MG | 600 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePLN-1474
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NoteResearch use only, not for human use.
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Brief DescriptionPLN-1474 is a potent αVβ1 inibitor with IC50 < 50nM (WO2021127483, compound 1)
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DescriptionPLN-1474 is a potent αVβ1 inibitor with IC50 < 50nM (WO2021127483, compound 1)
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In VitroPLN-1474 inhibits ανβ1 and ανβ6 with IC50s of <50 nM by solid phase assay.
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In VivoPLN-1474 (10 μM) decreases the expression level of profibrotic genes, including COL1A1 and TIMP1 in liver.PLN-1474 significantly reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in a mouse model of liver fibrosis.PLN-1474 (6-12 weeks) prophylactically or therapeutically blocks SMAD3 phosphorylation and significantly decreases OHP levels, collagen gene expression, and collagen deposition examined histologically in the CDAHFD NASH mouse model.
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SynonymsPLN1474
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PathwayCell Cycle/DNA Damage
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TargetIntegrin
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2408065-32-5
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Formula Weight431.57
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Molecular FormulaC24H37N3O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 83.33 mg/mL (193.09 )
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kassie F, et al. Intestinal microflora plays a crucial role in the genotoxicity of the cooked food mutagen 2-amino-3-methylimidazo [4,5-f]quinoline. Carcinogenesis. 2001 Oct;22(10):1721-5.
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