DS-70( α4 integrin inhibitor DS-70 )

Catalog No. M17080 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DS-70
Note

Research use only, not for human use.
Brief Description

DS-70 (α4 integrin inhibitor DS-70) is a novel potent α/β- peptidomimetic antagonist of α4 integrin.
Description

DS-70 (α4 integrin inhibitor DS-70) is a novel potent α/β- peptidomimetic antagonist of α4 integrin, binds to integrin α4β1 with nanomolar affinity; prevents the adhesion of α4 integrin-expressing cells, antagonizes VCAM-1-mediated degranulation of mast cells and eosinophils and ERK 1/2 phosphorylation; does not inhibit cell adhesion mediated by the leukocyte integrins aLb2 and aMb2 or by the Arg-GlyAsp (RGD)-binding integrins α5β1, αVβ3, αVβ5, αVβ6 and αIIbβ3; dose-dependently reduces the clinical symptoms of allergic conjunctivitis, conjunctival α4 integrin expression and conjunctival levels of chemokines and cytokines in ovalbumin-sensitized guinea pigs.
In Vitro

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In Vivo

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Synonyms

α4 integrin inhibitor DS-70
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

Integrin
Research Area

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Indication

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CAS Number

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Formula Weight

438.484
Molecular Formula

C23H26N4O5
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(S)-(1-(2-(4-(3-(o-tolyl)ureido)phenyl)acetyl)pyrrolidine-3-carbonyl)glycine

1. Dattoli SD, et al. Br J Pharmacol. 2018 Jul 26. doi: 10.1111/bph.14458.

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