MST-312

Research use only, not for human use.

MST-312 is an inhibitor of telomerase and can be used in studies about cancer, such as multiple myeloma.

MST-312 is an inhibitor of telomerase and can be used in studies about cancer, such as multiple myeloma.(In Vitro):In U-266 cells, MST-312 (2 μM) upregulates the pro-apoptotic gene Bax and down-regulates the anti-apoptotic gene Bcl-2 and suppresses the expression of c-Myc and hTERT genes. MST-312 (2-8 μM) reduces cellular viability in a dose dependent and time-dependent manner. MST-312 (2-8 μM) induces cell apoptosis in a dose-dependent manner.

Cell Viability Assay Cell Line:U-266 cells Concentration:2~8 μM Incubation Time:0~72 hours Result:The viability of U-266 cells was substantially decreased in a dose dependent and time-dependent manner, in response to exposure to MST-312.Apoptosis Analysis Cell Line:U-266 cells Concentration:2~8 μM Incubation Time:48 hours Result:Induced cell apoptosis in a dose-dependent manner.RT-PCR Cell Line:U-266 cells Concentration:2 μM Incubation Time:48 hours Result:Up-regulated the pro-apoptotic gene Bax and down-regulated the anti-apoptotic gene Bcl-2 and suppressed the expression of c-Myc and hTERT genes.

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Telomerase Inhibitor IX

Cell Cycle/DNA Damage

Telomerase

E3 Ligase Ligand-Linker Conjugate

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368449-04-1

380.356

C20H16N2O6

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (328.64 mM)

Oc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(O)c3O)c2)c1O

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(-20℃)

With Ice Pack

≥ 2 years