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360A
CAS No. 794458-56-3
360A( —— )
Catalog No. M20760 CAS No. 794458-56-3
360A is a stabilizing G-Quadruplex ligand and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 145 | In Stock |
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| 5MG | 210 | In Stock |
|
| 10MG | 320 | In Stock |
|
| 25MG | 530 | In Stock |
|
| 50MG | 730 | In Stock |
|
| 100MG | 1042 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name360A
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NoteResearch use only, not for human use.
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Brief Description360A is a stabilizing G-Quadruplex ligand and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
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Description360A is a stabilizing G-Quadruplex ligand and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
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In Vitro360A inhibits telomerase activity and stabilizes G-quadruplex, with an IC50 of 300 nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC50s of 4.8 ± 1.1 μM, 3.9 ± 0.4 μM, 8.4 ± 0.5 μM, >15 μM and 17.4 ± 1.2 μM, respectively. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetTelomerase
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RecptorTelomerase
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Research Area——
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Indication——
Chemical Information
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CAS Number794458-56-3
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Formula Weight449.5
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Molecular FormulaC27H23N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC[n+]1cc(NC(=O)c2cccc(n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12
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Chemical Name33'-((pyridine-26-dicarbonyl)bis(azanediyl))bis(1-methylquinolin-1-ium) iodide; (26-NN′-Methyl-quinolinio-3-yl)-pyridine dicarboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hwang I Mailliet P Hossard V et al. Investigating the Effect of Mono- and Dimeric 360A G-Quadruplex Ligands on Telomere Stability by Single Telomere Length Analysis (STELA)[J]. Molecules 2019 24(3).
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