Cart
sales@molnova.com
360A
CAS No. 794458-56-3
360A( —— )
Catalog No. M20760 CAS No. 794458-56-3
360A is a stabilizing G-Quadruplex ligand and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 138 | In Stock |
|
| 5MG | 199 | In Stock |
|
| 10MG | 303 | In Stock |
|
| 25MG | 502 | In Stock |
|
| 50MG | 707 | In Stock |
|
| 100MG | 1008 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product Name360A
-
NoteResearch use only, not for human use.
-
Brief Description360A is a stabilizing G-Quadruplex ligand and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
-
Description360A is a stabilizing G-Quadruplex ligand and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
-
In Vitro360A inhibits telomerase activity and stabilizes G-quadruplex, with an IC50 of 300 nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC50s of 4.8 ± 1.1 μM, 3.9 ± 0.4 μM, 8.4 ± 0.5 μM, >15 μM and 17.4 ± 1.2 μM, respectively. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions.
-
In Vivo——
-
Synonyms——
-
PathwayCell Cycle/DNA Damage
-
TargetTelomerase
-
RecptorTelomerase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number794458-56-3
-
Formula Weight449.5
-
Molecular FormulaC27H23N5O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC[n+]1cc(NC(=O)c2cccc(n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12
-
Chemical Name33'-((pyridine-26-dicarbonyl)bis(azanediyl))bis(1-methylquinolin-1-ium) iodide; (26-NN′-Methyl-quinolinio-3-yl)-pyridine dicarboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Hwang I Mailliet P Hossard V et al. Investigating the Effect of Mono- and Dimeric 360A G-Quadruplex Ligands on Telomere Stability by Single Telomere Length Analysis (STELA)[J]. Molecules 2019 24(3).
molnova catalog
related products
-
MST-312
MST-312 is an inhibitor of telomerase and can be used in studies about cancer, such as multiple myeloma.
-
Ceramides Mixture
Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle arrest, growth inhibition, and modulation of telomerase activity.Endogenous Ceramides inhibits mRNA synthesis of telomerase reverse transcriptase and telomerase activity via inactivation of the c-Myc transcription factor in the A549 human lung adenocarcinoma cell line.
-
Adefovir
Adefovir is an acyclic nucleoside phosphonate that acts as a reverse transcriptase inhibitor?used for treatment of hepatitis B and herpes simplex virus infection.
