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N-Desalkylflurazepam

CAS No. 2886-65-9

N-Desalkylflurazepam( Norfludiazepam )

Catalog No. M28291 CAS No. 2886-65-9

N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC 50 values of 55 μM and 37 μM for Ca v 1.2 and Ca v 1.3 , respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    N-Desalkylflurazepam
  • Note
    Research use only, not for human use.
  • Brief Description
    N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC 50 values of 55 μM and 37 μM for Ca v 1.2 and Ca v 1.3 , respectively.
  • Description
    N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC 50 values of 55 μM and 37 μM for Ca v 1.2 and Ca v 1.3 , respectively.(In Vitro):Flurazepam's long-acting metabolite, N-Desalkylflurazepam, reduces the amplitudes of all the evoked potentials (EPs) components .
  • In Vitro
    Flurazepam's long-acting metabolite, N-Desalkylflurazepam, reduces the amplitudes of all the evoked potentials (EPs) components.
  • In Vivo
    ——
  • Synonyms
    Norfludiazepam
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    S-adenosylmethionine decarboxylase (SAMDC)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2886-65-9
  • Formula Weight
    288.71
  • Molecular Formula
    C15H10ClFN2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (346.38 mM)
  • SMILES
    Fc1ccccc1C1=NCC(=O)Nc2ccc(Cl)cc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58(17):3883-90.
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