GSK-7975A( GSK-7975 | GSK7975 )

Catalog No. M11017 CAS No. 1253186-56-9

A selective CRAC channel blocker that inhibits store-operated Ca(2+) entry with IC50 of 3.4 uM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	89	In Stock
2MG	50	In Stock
5MG	81	In Stock
10MG	132	In Stock
25MG	264	In Stock
50MG	390	In Stock
100MG	589	In Stock
200MG	Get Quote	In Stock
500MG	1228	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

GSK-7975A
Note

Research use only, not for human use.
Brief Description

A selective CRAC channel blocker that inhibits store-operated Ca(2+) entry with IC50 of 3.4 uM.
Description

A selective CRAC channel blocker that inhibits store-operated Ca(2+) entry with IC50 of 3.4 uM; shows little or no effect on the physiological Ca(2+) spiking evoked by acetylcholine or cholecystokinin; inhibits the release of mast cell mediators and T-cell cytokines from multiple human and rat preparations.
In Vitro

——
In Vivo

——
Synonyms

GSK-7975 | GSK7975
Pathway

GPCR/G Protein
Target

Calcium Channel
Recptor

Calcium Channel
Research Area

——
Indication

——

Chemical Information

CAS Number

1253186-56-9
Formula Weight

397.305
Molecular Formula

C18H12F5N3O2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 90 mg/mL 226.53 mM
SMILES

O=C(NC1=NN(CC2=CC=C(O)C=C2C(F)(F)F)C=C1)C3=C(F)C=CC=C3F
Chemical Name

2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Gerasimenko JV, et al. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13186-91. 2. Rice LV, et al. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57. 3. Derler I, et al. Cell Calcium. 2013 Feb;53(2):139-51.

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