Cart
sales@molnova.com
GSK-7975A
CAS No. 1253186-56-9
GSK-7975A( GSK-7975 | GSK7975 )
Catalog No. M11017 CAS No. 1253186-56-9
A selective CRAC channel blocker that inhibits store-operated Ca(2+) entry with IC50 of 3.4 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | Get Quote |
|
| 10MG | 140 | Get Quote |
|
| 25MG | 302 | Get Quote |
|
| 50MG | 488 | Get Quote |
|
| 100MG | 696 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameGSK-7975A
-
NoteResearch use only, not for human use.
-
Brief DescriptionA selective CRAC channel blocker that inhibits store-operated Ca(2+) entry with IC50 of 3.4 uM.
-
DescriptionA selective CRAC channel blocker that inhibits store-operated Ca(2+) entry with IC50 of 3.4 uM; shows little or no effect on the physiological Ca(2+) spiking evoked by acetylcholine or cholecystokinin; inhibits the release of mast cell mediators and T-cell cytokines from multiple human and rat preparations.
-
In Vitro——
-
In Vivo——
-
SynonymsGSK-7975 | GSK7975
-
PathwayGPCR/G Protein
-
TargetCalcium Channel
-
RecptorCalcium Channel
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1253186-56-9
-
Formula Weight397.305
-
Molecular FormulaC18H12F5N3O2
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 90 mg/mL 226.53 mM
-
SMILESO=C(NC1=NN(CC2=CC=C(O)C=C2C(F)(F)F)C=C1)C3=C(F)C=CC=C3F
-
Chemical Name2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Gerasimenko JV, et al. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13186-91.
2. Rice LV, et al. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57.
3. Derler I, et al. Cell Calcium. 2013 Feb;53(2):139-51.
molnova catalog
related products
-
L-Phenylalanine-15N
L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) is the 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli . L-Phenylalanine is a α2δ subunit of voltage-dependent Ca + channels antagonist with a K i of 980 nM.
-
Etripamil
Etripamil displays atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells. Etripamil is an antagonist of short-acting L-type calcium-channel.
-
Calcium Channel anta...
Calcium Channel antagonist 3 is a voltage-gated calcium channel inhibitor (IC50 : 5-20 μM).
