VU0360172( VU-0360172 | VU 0360172 )

Catalog No. M27938 CAS No. 1310012-12-4

VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).

Purity : >98% (HPLC)

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Biological Information

Product Name

VU0360172
Note

Research use only, not for human use.
Brief Description

VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).
Description

VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).(In Vivo):VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice.
In Vitro

——
In Vivo

——
Synonyms

VU-0360172 | VU 0360172
Pathway

Neuroscience
Target

GluR
Recptor

CK1
Research Area

——
Indication

——

Chemical Information

CAS Number

1310012-12-4
Formula Weight

294.329
Molecular Formula

C18H15FN2O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 83.33 mg/mL (283.13 mM)
SMILES

Fc1cccc(c1)C#Cc1ccc(cn1)C(=O)NC1CCC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Ana MARTíNEZ GIL, et al. Preparation of substituted benzothiazoles as casein kinase 1 inhibitors for the treatment of human diseases. WO2014114825A1

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