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MLS1547

CAS No. 315698-36-3

MLS1547( MLS-1547 | MLS 1547 | MLS000051547 )

Catalog No. M27901 CAS No. 315698-36-3

MLS1547 is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MLS1547
  • Note
    Research use only, not for human use.
  • Brief Description
    MLS1547 is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay.
  • Description
    MLS1547 is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay.(In Vitro):MLS1547 fully antagonizes dopamine-mediated β-arrestin recruitment to the D2 dopamine receptor with an IC50 of 9.9 μM in the DiscoveRx assay and 3.8 μM in the BRET assay. MLS1547 is found to completely displace [3H]methylspiperone binding to the D2 dopamine receptor, with a calculated Ki of 1.2 μM.
  • In Vitro
    MLS1547 fully antagonizes dopamine-mediated β-arrestin recruitment to the D2R in the DiscoveRx assay, with an IC50 of 9.9 μM. Similar results were obtained when MLS1547 was examined for antagonist activity in the D2R β-arrestin BRET assay, demonstrating an IC50 of 3.8 μM. MLS1547 is found to completely displace [3H]methylspiperone binding to the D2R, with a calculated Ki of 1.2 μM.
  • In Vivo
    ——
  • Synonyms
    MLS-1547 | MLS 1547 | MLS000051547
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    SOD1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    315698-36-3
  • Formula Weight
    354.84
  • Molecular Formula
    C19H19ClN4O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (93.93 mM)
  • SMILES
    Oc1c(CN2CCN(CC2)c2ccccn2)cc(Cl)c2cccnc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chisholm CL, et al. Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin. Oncotarget. 2016 Oct 31.
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