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GDC0575 monohydrochloride
CAS No. 1196504-54-7
GDC0575 monohydrochloride( —— )
Catalog No. M27878 CAS No. 1196504-54-7
GDC-0575 is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 2MG | 50 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 105 | In Stock |
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| 25MG | 187 | In Stock |
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| 50MG | 263 | In Stock |
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| 100MG | 368 | In Stock |
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| 200MG | 537 | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGDC0575 monohydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionGDC-0575 is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
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DescriptionGDC-0575 is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetChk
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RecptorhSGLT2
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Research Area——
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Indication——
Chemical Information
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CAS Number1196504-54-7
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Formula Weight414.73
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Molecular FormulaC16H21BrClN5O
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.N[C@@H]1CCCN(C1)c1c(Br)cnc2[nH]cc(NC(=O)C3CC3)c12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Miao Z, et al. Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects. Drug Metab Dispos. 2013 Feb;41(2):445-56.
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