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Debromohymenialdisine
CAS No. 75593-17-8
Debromohymenialdisine( SKF-108753 | SKF108753 )
Catalog No. M15875 CAS No. 75593-17-8
A marine sponge alkaloid that inhibits Chk1 and Chk2 with IC50 of 3 and 3.5 uM, respectively; also inhibits MAP kinase kinase 1 (IC50=881 nM), GSK3β (IC50=1.39 uM), and CDK5/p25 (IC50=9.12 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 1004 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameDebromohymenialdisine
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NoteResearch use only, not for human use.
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Brief DescriptionA marine sponge alkaloid that inhibits Chk1 and Chk2 with IC50 of 3 and 3.5 uM, respectively; also inhibits MAP kinase kinase 1 (IC50=881 nM), GSK3β (IC50=1.39 uM), and CDK5/p25 (IC50=9.12 uM).
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DescriptionA marine sponge alkaloid that inhibits Chk1 and Chk2 with IC50 of 3 and 3.5 uM, respectively; also inhibits MAP kinase kinase 1 (IC50=881 nM), GSK3β (IC50=1.39 uM), and CDK5/p25 (IC50=9.12 uM), does not significantly affect ATM and ATR; blocks G2 arrest in cancer cells.
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In VitroDebromohymenialdisine has moderate inhibitory activity with an IC50 value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay.
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In Vivo——
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SynonymsSKF-108753 | SKF108753
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PathwayAngiogenesis
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TargetChk
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RecptorChk
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Research Area——
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Indication——
Chemical Information
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CAS Number75593-17-8
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Formula Weight245.2
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Molecular FormulaC11H11N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=C/2C=CN1)NCCC2=C3N=C(N)NC/3=O
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Chemical Name(4Z)-4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-4,5,6,7-tetrahydro-pyrrolo[2,3-c]azepin-8(1H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Curman D, et al. J Biol Chem. 2001 May 25;276(21):17914-9.
2. Saleem RS, et al. Bioorg Med Chem. 2012 Feb 15;20(4):1475-81.
3. Jobson AG, et al. Mol Pharmacol. 2007 Oct;72(4):876-84.
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