Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - TRP/TRPV Channel - MK6-83

MK6-83

CAS No. 1062271-24-2

MK6-83( MK6 83 | MK683 )

Catalog No. M27779 CAS No. 1062271-24-2

MK6-83 is the transient receptor potential channel ML3 agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 69 In Stock
2MG 39 In Stock
5MG 63 In Stock
10MG 92 In Stock
25MG 187 In Stock
50MG 321 In Stock
100MG 548 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    MK6-83
  • Note
    Research use only, not for human use.
  • Brief Description
    MK6-83 is the transient receptor potential channel ML3 agonist.
  • Description
    MK6-83 is the transient receptor potential channel ML3 agonist.(In Vitro):MK6-83(0.2-30 μM) shows no signs of cytotoxicity. Administration of 0-10 μM MK6-83 for 24 hours is efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells and has no significant effect on lysosomes isolated from TRPML1-/- fibroblasts.
  • In Vitro
    Cell Viability Assay.Cell Line:Lysosomes isolated from fibroblast cell lines derived from MLIV patients carrying either the F408D, the R403C or the V446L mutation.Concentration:0-10 μM.Incubation Time:24 h.Result:Efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells.
  • In Vivo
    ——
  • Synonyms
    MK6 83 | MK683
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    Akt| mTOR| Microtubule/Tubulin| Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1062271-24-2
  • Formula Weight
    336.47
  • Molecular Formula
    C16H20N2O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (74.30 mM)
  • SMILES
    Cc1ccc(s1)S(=O)(=O)Nc1ccccc1N1CCCCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jason E Faris,et al. A phase 2 study of oral MKC-1, an inhibitor of importin-β, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer.Invest New Drugs. 2012 Aug;30(4):1614-20.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • AMG-9810

    A potent, selective and competitive TRPV1 antagonist with IC50 of 24.5 and 85.6 nM for human and rat TRPV1, repectively.

  • Pyr6

    Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.Pyr3 is selective inhibitor of TRPC3, inhibited Orai1- and TRPC3-mediated Ca(2+) entry and currents as well as mast cell activation with similar potency.?

  • TRPA1-IN-2

    TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM.TRPA1-IN-2 has anti-inflammatory activity.

Sign In Join Free