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MK6-83
CAS No. 1062271-24-2
MK6-83( MK6 83 | MK683 )
Catalog No. M27779 CAS No. 1062271-24-2
MK6-83 is the transient receptor potential channel ML3 agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 69 | In Stock |
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| 2MG | 39 | In Stock |
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| 5MG | 63 | In Stock |
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| 10MG | 92 | In Stock |
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| 25MG | 187 | In Stock |
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| 50MG | 321 | In Stock |
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| 100MG | 548 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMK6-83
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NoteResearch use only, not for human use.
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Brief DescriptionMK6-83 is the transient receptor potential channel ML3 agonist.
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DescriptionMK6-83 is the transient receptor potential channel ML3 agonist.(In Vitro):MK6-83(0.2-30 μM) shows no signs of cytotoxicity. Administration of 0-10 μM MK6-83 for 24 hours is efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells and has no significant effect on lysosomes isolated from TRPML1-/- fibroblasts.
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In VitroCell Viability Assay.Cell Line:Lysosomes isolated from fibroblast cell lines derived from MLIV patients carrying either the F408D, the R403C or the V446L mutation.Concentration:0-10 μM.Incubation Time:24 h.Result:Efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells.
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In Vivo——
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SynonymsMK6 83 | MK683
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorAkt| mTOR| Microtubule/Tubulin| Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number1062271-24-2
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Formula Weight336.47
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Molecular FormulaC16H20N2O2S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (74.30 mM)
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SMILESCc1ccc(s1)S(=O)(=O)Nc1ccccc1N1CCCCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jason E Faris,et al. A phase 2 study of oral MKC-1, an inhibitor of importin-β, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer.Invest New Drugs. 2012 Aug;30(4):1614-20.
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