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Co 101244 hydrochloride
CAS No. 193356-17-1
Co 101244 hydrochloride( 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride )
Catalog No. M27615 CAS No. 193356-17-1
Co 101244 hydrochloride is an NR2B-containing NMDA receptor antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | Get Quote |
|
| 10MG | 143 | Get Quote |
|
| 25MG | 290 | Get Quote |
|
| 50MG | 462 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCo 101244 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCo 101244 hydrochloride is an NR2B-containing NMDA receptor antagonist.
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DescriptionCo 101244 hydrochloride is an NR2B-containing NMDA receptor antagonist.(In Vitro):Co 101244 enhances neuroprotection and reduces NMDA-evoked Ca2+ elevations effectively .(In Vivo):Administration of 1 mg/kg s.c. Co 101244 displayed antidyskinetic effects with the reduction of 67% while sparing levodopa motor benefit.
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In VitroCo 101244 effectively reduces NMDA-evoked Ca2+ elevations while enhancing neuroprotection.
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In VivoCo 101244 (0.1, 1 mg/kg s.c.) displayed antidyskinetic effects (67 and 71% reduction, respectively) while sparing levodopa motor benefit.
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Synonyms4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride
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PathwayMembrane Transporter/Ion Channel
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TargetNMDAR
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Recptorinhibitor of DNA binding (ID)
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Research Area——
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Indication——
Chemical Information
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CAS Number193356-17-1
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Formula Weight377.91
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Molecular FormulaC21H28ClNO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (264.62 mM)
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SMILESCl.Cc1ccc(CC2(O)CCN(CCOc3ccc(O)cc3)CC2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wojnarowicz PM, et al. A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep. 2019 Oct 1;29(1):62-75.e7.
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