Co 101244 hydrochloride( 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride )

Catalog No. M27615 CAS No. 193356-17-1

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Product Name

Co 101244 hydrochloride
Note

Research use only, not for human use.
Brief Description

Co 101244 hydrochloride is an NR2B-containing NMDA receptor antagonist.
Description

Co 101244 hydrochloride is an NR2B-containing NMDA receptor antagonist.(In Vitro):Co 101244 enhances neuroprotection and reduces NMDA-evoked Ca2+ elevations effectively .(In Vivo):Administration of 1 mg/kg s.c. Co 101244 displayed antidyskinetic effects with the reduction of 67% while sparing levodopa motor benefit.
In Vitro

Co 101244 effectively reduces NMDA-evoked Ca2+ elevations while enhancing neuroprotection.
In Vivo

Co 101244 (0.1, 1 mg/kg s.c.) displayed antidyskinetic effects (67 and 71% reduction, respectively) while sparing levodopa motor benefit.
Synonyms

4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride
Pathway

Membrane Transporter/Ion Channel
Target

NMDAR
Recptor

inhibitor of DNA binding (ID)
Research Area

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Indication

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1.Wojnarowicz PM, et al. A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep. 2019 Oct 1;29(1):62-75.e7.

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