Co 101244 hydrochloride

CAS No. 193356-17-1

Co 101244 hydrochloride( 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride )

Catalog No. M27615 CAS No. 193356-17-1

Co 101244 hydrochloride is an NR2B-containing NMDA receptor antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 33 In Stock
5MG 55 In Stock
10MG 90 In Stock
25MG 183 In Stock
50MG 276 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Co 101244 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Co 101244 hydrochloride is an NR2B-containing NMDA receptor antagonist.
  • Description
    Co 101244 hydrochloride is an NR2B-containing NMDA receptor antagonist.(In Vitro):Co 101244 enhances neuroprotection and reduces NMDA-evoked Ca2+ elevations effectively .(In Vivo):Administration of 1 mg/kg s.c. Co 101244 displayed antidyskinetic effects with the reduction of 67% while sparing levodopa motor benefit.
  • In Vitro
    Co 101244 effectively reduces NMDA-evoked Ca2+ elevations while enhancing neuroprotection.
  • In Vivo
    Co 101244 (0.1, 1 mg/kg s.c.) displayed antidyskinetic effects (67 and 71% reduction, respectively) while sparing levodopa motor benefit.
  • Synonyms
    4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NMDAR
  • Recptor
    inhibitor of DNA binding (ID)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    193356-17-1
  • Formula Weight
    377.91
  • Molecular Formula
    C21H28ClNO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (264.62 mM)
  • SMILES
    Cl.Cc1ccc(CC2(O)CCN(CCOc3ccc(O)cc3)CC2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wojnarowicz PM, et al. A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep. 2019 Oct 1;29(1):62-75.e7.
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