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Co 101244 hydrochloride

CAS No. 193356-17-1

Co 101244 hydrochloride( 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride )

Catalog No. M27615 CAS No. 193356-17-1

Co 101244 hydrochloride is an NR2B-containing NMDA receptor antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Co 101244 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Co 101244 hydrochloride is an NR2B-containing NMDA receptor antagonist.
  • Description
    Co 101244 hydrochloride is an NR2B-containing NMDA receptor antagonist.(In Vitro):Co 101244 enhances neuroprotection and reduces NMDA-evoked Ca2+ elevations effectively .(In Vivo):Administration of 1 mg/kg s.c. Co 101244 displayed antidyskinetic effects with the reduction of 67% while sparing levodopa motor benefit.
  • In Vitro
    Co 101244 effectively reduces NMDA-evoked Ca2+ elevations while enhancing neuroprotection.
  • In Vivo
    Co 101244 (0.1, 1 mg/kg s.c.) displayed antidyskinetic effects (67 and 71% reduction, respectively) while sparing levodopa motor benefit.
  • Synonyms
    4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NMDAR
  • Recptor
    inhibitor of DNA binding (ID)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    193356-17-1
  • Formula Weight
    377.91
  • Molecular Formula
    C21H28ClNO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (264.62 mM)
  • SMILES
    Cl.Cc1ccc(CC2(O)CCN(CCOc3ccc(O)cc3)CC2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wojnarowicz PM, et al. A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep. 2019 Oct 1;29(1):62-75.e7.
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