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TRPC6-PAM-C20
CAS No. 667427-75-0
TRPC6-PAM-C20( 3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one )
Catalog No. M28129 CAS No. 667427-75-0
TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 with an EC50 of 2.37 μM. TRPC6-PAM-C20 enhances OAG-induced platelet aggregation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 466 | In Stock |
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| 5MG | 432 | In Stock |
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| 10MG | 638 | In Stock |
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| 25MG | 1007 | In Stock |
|
| 50MG | 1330 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTRPC6-PAM-C20
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NoteResearch use only, not for human use.
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Brief DescriptionTRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 with an EC50 of 2.37 μM. TRPC6-PAM-C20 enhances OAG-induced platelet aggregation.
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DescriptionTRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 with an EC50 of 2.37 μM. TRPC6-PAM-C20 enhances OAG-induced platelet aggregation.
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In Vitro——
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In Vivo——
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Synonyms3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorGLP-1
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Research Area——
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Indication——
Chemical Information
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CAS Number667427-75-0
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Formula Weight363.413
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Molecular FormulaC22H21NO4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 33.33 mg/mL (91.71 mM)
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SMILESCOc1cc2CC(C)(C)N=C(c2cc1OC)c1cc2ccccc2oc1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Decara JM, et al. Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity". J Med Chem. 2022 Apr 14;65(7):5449-5461.
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