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A 425619
CAS No. 581809-67-8
A 425619( 1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA )
Catalog No. M22193 CAS No. 581809-67-8
A 425619 is a potent TRPV1 antagonistsystemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 178 | In Stock |
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| 5MG | 169 | In Stock |
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| 10MG | 258 | In Stock |
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| 25MG | 426 | In Stock |
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| 50MG | 586 | In Stock |
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| 100MG | 792 | In Stock |
|
| 200MG | 1051 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameA 425619
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NoteResearch use only, not for human use.
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Brief DescriptionA 425619 is a potent TRPV1 antagonistsystemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.
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DescriptionA 425619 is a potent TRPV1 antagonistsystemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.
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In Vitro——
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In Vivo——
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Synonyms1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRPV1
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Research Area——
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Indication——
Chemical Information
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CAS Number581809-67-8
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Formula Weight345.33
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Molecular FormulaC18H14F3N3O
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Purity>98% (HPLC)
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SolubilityDMSO:34.5 mg/mL (100 mM; Need ultrasonic)
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SMILESFC(F)(F)c1ccc(CNC(=O)Nc2cccc3cnccc23)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chakrabarti S , Pattison L A , Singhal K , et al. Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner[J]. Neuropharmacology, 2018, 143.
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