Cart
sales@molnova.com
CGP 3466B maleate
CAS No. 200189-97-5
CGP 3466B maleate( Omigapil (Maleate) | Omigapil maleate )
Catalog No. M27464 CAS No. 200189-97-5
Omigapil maleate is an orally bioavailable GAPDH nitrosylation inhibitor. Omigapil maleate abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 62 | In Stock |
|
| 2MG | 29 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCGP 3466B maleate
-
NoteResearch use only, not for human use.
-
Brief DescriptionOmigapil maleate is an orally bioavailable GAPDH nitrosylation inhibitor. Omigapil maleate abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice.
-
DescriptionOmigapil maleate is an orally bioavailable GAPDH nitrosylation inhibitor. Omigapil maleate abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil maleate has the potential for the research of Alzheimer's disease. Omigapil maleate (CGP3446B maleate) is a apoptosis inhibitor. Omigapil maleate can be used for the research of congenital muscular dystrophy (CMD).(In Vivo):Treatment with Omigapil (0.1 mg/kg) in 12-week-old dyW/ mag mice results in improved muscle regeneration and increased force .
-
In Vitro——
-
In VivoAnimal Model:12-week-old dyW/ mag miceDosage:0.1 mg/kg Administration:For the first week of drug treatment, administered once daily by intraperitoneal injection. After weaning (3 weeks of age), applied once daily by oral gavage.Result:Reduced the muscle fibre loss. Many of the functional parameters were significantly improved by omigapil.
-
SynonymsOmigapil (Maleate) | Omigapil maleate
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorBacterial
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number200189-97-5
-
Formula Weight391.42
-
Molecular FormulaC23H21NO5
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 50 mg/mL (127.74 mM)
-
SMILESC(=C\C(O)=O)\C(O)=O.C(N(CC#C)C)C=1C=2C(OC=3C(C1)=CC=CC3)=CC=CC2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Ríos F, et al. Anaerobic digestion of amine-oxide-based surfactants: biodegradation kinetics and inhibitory effects. Biodegradation. 2017 Aug;28(4):303-312.
molnova catalog
related products
-
Curzerene
Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene induces cell apoptosis[1].Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression.
-
Kinsenoside;(+)-Kins...
Kinsenoside shows significant antihepatotoxic and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury as well as improving its function it could promote the glucose tolerance of acute glucose increase in both diabetic and normal healthy rats.
-
Kinetin riboside
A cytokinin analog that displays potent antiproliferative activity against various human cancer cell lines.
