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AMTB hydrochloride
CAS No. 926023-82-7
AMTB hydrochloride( AMTB HCl )
Catalog No. M27139 CAS No. 926023-82-7
AMTB is a novel TRPM8 channel blocker and is effective for pain and urinary diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 80 | In Stock |
|
| 5MG | 68 | In Stock |
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| 10MG | 122 | In Stock |
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| 25MG | 264 | In Stock |
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| 50MG | 439 | In Stock |
|
| 100MG | 648 | In Stock |
|
| 200MG | 920 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAMTB hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionAMTB is a novel TRPM8 channel blocker and is effective for pain and urinary diseases.
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DescriptionAMTB is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive reflex responses in the rat.(In Vivo):For rats, AMTB (10 mg/kg) significantly attenuated reflex responses to noxious urinary bladder distension (UBD) to 5.42 and 56.51% of the maximal visceromotor reflex (VMR) response and pressor response, respectively. The ID50 value on VMR response was 2.42 +/- 0.46 mg/kg .
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In VitroAMTB hydrochloride blocks veratridine-induced membrane potential changes at each NaV1 isoform (pIC50s ranging 4.83-5.69 for NaV1.1- NaV1.8). AMTB hydrochloride decreases viable cell number in MDA-MB-231 and SK-BR-3 breast cancer cell lines (30 and 100 μM), and also reduces the migration of MDA-MB-231 cells (30 μM).
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In VivoIn the anesthetized rat, AMTB (3 mg/kg; intravenous) hydrochloride decreases the frequency of volume-induced bladder contractions, without reducing the amplitude of contraction.
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SynonymsAMTB HCl
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorPPARδ
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Research Area——
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Indication——
Chemical Information
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CAS Number926023-82-7
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Formula Weight430.99
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Molecular FormulaC23H27ClN2O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (232.02 mM)
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SMILESCl.Cc1cccc(COc2ccccc2C(=O)N(CCCN)Cc2cccs2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Michael Downes, et al. Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof. Patent WO2017062468A1.
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