AMTB hydrochloride( AMTB HCl )

Catalog No. M27139 CAS No. 926023-82-7

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Product Name

AMTB hydrochloride
Note

Research use only, not for human use.
Brief Description

AMTB is a novel TRPM8 channel blocker and is effective for pain and urinary diseases.
Description

AMTB is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive reflex responses in the rat.(In Vivo):For rats, AMTB (10 mg/kg) significantly attenuated reflex responses to noxious urinary bladder distension (UBD) to 5.42 and 56.51% of the maximal visceromotor reflex (VMR) response and pressor response, respectively. The ID50 value on VMR response was 2.42 +/- 0.46 mg/kg .
In Vitro

AMTB hydrochloride blocks veratridine-induced membrane potential changes at each NaV1 isoform (pIC50s ranging 4.83-5.69 for NaV1.1- NaV1.8). AMTB hydrochloride decreases viable cell number in MDA-MB-231 and SK-BR-3 breast cancer cell lines (30 and 100 μM), and also reduces the migration of MDA-MB-231 cells (30 μM).
In Vivo

In the anesthetized rat, AMTB (3 mg/kg; intravenous) hydrochloride decreases the frequency of volume-induced bladder contractions, without reducing the amplitude of contraction.
Synonyms

AMTB HCl
Pathway

Membrane Transporter/Ion Channel
Target

TRP/TRPV Channel
Recptor

PPARδ
Research Area

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Indication

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1.Michael Downes, et al. Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof. Patent WO2017062468A1.

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