Cart
sales@molnova.com
TRPV4 agonist-1 free base
CAS No. 2314467-59-7
TRPV4 agonist-1 free base( OUN67600 )
Catalog No. M24056 CAS No. 2314467-59-7
TRPV4 agonist-1 free base is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 73 | In Stock |
|
| 2MG | 33 | In Stock |
|
| 5MG | 56 | In Stock |
|
| 10MG | 89 | In Stock |
|
| 25MG | 179 | In Stock |
|
| 50MG | 277 | In Stock |
|
| 100MG | 384 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTRPV4 agonist-1 free base
-
NoteResearch use only, not for human use.
-
Brief DescriptionTRPV4 agonist-1 free base is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
-
DescriptionTRPV4 agonist-1 free base is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
-
In VitroTRPV4 agonist-1 (Compound 36) exhibits significantly increased potency (ECmax: 20 nM in the SOX9 reporter assay). TRPV4 agonist-1 is inactive against TRPV1 channels.
-
In Vivo——
-
SynonymsOUN67600
-
PathwayMembrane Transporter/Ion Channel
-
TargetTRP/TRPV Channel
-
RecptorTRPV4
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2314467-59-7
-
Formula Weight448.46
-
Molecular FormulaC25H22F2N4O2
-
Purity>98% (HPLC)
-
SolubilityDMSO:83.33 mg/mL?(185.81 mM;?Need ultrasonic)
-
SMILESCN1CCN(CC1)C2=NC3=C(C=CC=C3F)C(=O)N2C4=CC=C(C=C4)OC5=CC=C(C=C5)F
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Atobe M, et al. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J Med Chem. 2019 Jan 28.
molnova catalog
related products
-
SB269970 HCl
SB269970 HCl, a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors.
-
JYL 1421
JYL 1421 is an antagonist of TRPV1 receptor (IC50 = 8 nM).
-
Methyl Kakuol
Methyl Kakuol is an agonist of TRPA1 with an EC50 of 0.27 μM and can be used in studies about acting as an active ingredient in MBST constituent Asiasari Radix.
