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TRPV4 agonist-1 free base

CAS No. 2314467-59-7

TRPV4 agonist-1 free base( OUN67600 )

Catalog No. M24056 CAS No. 2314467-59-7

TRPV4 agonist-1 free base is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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1 mL x 10 mM in DMSO 73 In Stock
2MG 33 In Stock
5MG 56 In Stock
10MG 89 In Stock
25MG 179 In Stock
50MG 277 In Stock
100MG 384 In Stock
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Biological Information

  • Product Name
    TRPV4 agonist-1 free base
  • Note
    Research use only, not for human use.
  • Brief Description
    TRPV4 agonist-1 free base is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
  • Description
    TRPV4 agonist-1 free base is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
  • In Vitro
    TRPV4 agonist-1 (Compound 36) exhibits significantly increased potency (ECmax: 20 nM in the SOX9 reporter assay). TRPV4 agonist-1 is inactive against TRPV1 channels.
  • In Vivo
    ——
  • Synonyms
    OUN67600
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRPV4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2314467-59-7
  • Formula Weight
    448.46
  • Molecular Formula
    C25H22F2N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:83.33 mg/mL?(185.81 mM;?Need ultrasonic)
  • SMILES
    CN1CCN(CC1)C2=NC3=C(C=CC=C3F)C(=O)N2C4=CC=C(C=C4)OC5=CC=C(C=C5)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Atobe M, et al. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J Med Chem. 2019 Jan 28.
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