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Zotepine
CAS No. 26615-21-4
Zotepine( —— )
Catalog No. M27130 CAS No. 26615-21-4
Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 44 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 49 | In Stock |
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| 25MG | 101 | In Stock |
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| 50MG | 145 | In Stock |
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| 100MG | 212 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameZotepine
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NoteResearch use only, not for human use.
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Brief DescriptionZotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively.
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DescriptionZotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second-generation antipsychotic with a primary use as a treatment for schizophrenia, although clinical trials have been conducted into its efficacy as an antimanic agent in patients with acute bipolar mania.
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In VitroZotepine shows multiple antagonistic profiles with strong affinities to α1-adrenergic, α2-adrenergic, Dopamine D2, Histamine H1, Muscarinic, 5-HT1A, 5-HT1D, 5-HT2A, and 5-HT2C receptors, with Kds of 7.3, 180, 8, 3.3, 330, 280, 80, 2.6, 3.2 nM, respectively.
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In VivoZotepine (1-3 mg/kg; a single i.p.) dose-dependently increases noradrenaline, dopamine, GABA, and glutamate release without affecting 5-HT levels in the medial prefrontal cortex of rats. Animal Model:Male Sprague-Dawley rats (250-300 g)Dosage:1, 3 mg/kg Administration:A single i.p.Result:Increased noradrenaline, dopamine, GABA, and glutamate release without affecting 5-HT levels in the medial prefrontal cortex.Increased neuronal firing frequencies in the VTA, DRN, LC and MTN in a dose-dependent manner.
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Synonyms——
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorGpx4
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Research Area——
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Indication——
Chemical Information
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CAS Number26615-21-4
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Formula Weight331.86
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Molecular FormulaC18H18ClNOS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (75.33 mM)
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SMILESCN(C)CCOC1=Cc2ccccc2Sc2ccc(Cl)cc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kathman SG, et al. A masked zinger to block GPX4. Nat Chem Biol. 2020;16(5):482-483.
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