Cart
sales@molnova.com
Talampanel
CAS No. 161832-65-1
Talampanel( GYKI-53773 | LY-300164 )
Catalog No. M26835 CAS No. 161832-65-1
Talampanel is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 53 | In Stock |
|
| 2MG | 30 | In Stock |
|
| 5MG | 47 | In Stock |
|
| 10MG | 70 | In Stock |
|
| 25MG | 140 | In Stock |
|
| 50MG | 230 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTalampanel
-
NoteResearch use only, not for human use.
-
Brief DescriptionTalampanel is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity.
-
DescriptionTalampanel is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models.(In Vivo):Talampanel (p.o.; 5 mg/kg; once a day; 2 weeks) decreases motoneuronal calcium in a mouse model of ALS .
-
In Vitro——
-
In VivoTalampanel (orally administration; 5 mg/kg; once a day; 2 weeks) reduces motoneuronal calcium in a mouse model of ALS, but its efficacy declines as the disease progresses. Animal Model:Female mutant SOD1 Tg mice Dosage:5 mg/kg Administration:Orally administration; 5 mg/kg; once a day; 2 weeks Result:Had a significant effect in reducing the calcium level only at the age of 12 weeks.
-
SynonymsGYKI-53773 | LY-300164
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorASK1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number161832-65-1
-
Formula Weight337.379
-
Molecular FormulaC19H19N3O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (296.41 mM)
-
SMILESC[C@@H]1Cc2cc3OCOc3cc2C(=NN1C(C)=O)c1ccc(N)cc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Kawarazaki Y, Ichijo H, Naguro I. Apoptosis signal-regulating kinase 1 as a therapeutic target. Expert Opin Ther Targets. 2014 Jun;18(6):651-64.
molnova catalog
related products
-
Lanperisone HCl
Lanperisone HCl (NK 433) is a novel orally available centrally acting muscle relaxant with anticancer activity and inhibits mono- and polysynaptic reflex potentials.
-
Declopramide
Declopramide (OXI-104) is a novel chemosensitizer with antitumor activity that induces apoptosis and can be used to study colorectal cancer and inflammatory bowel disease.
-
AFMK
AFMK is an active metabolite of Melatonin with antioxidant and free radical scavenging activity. AFMK is a modulator of apoptosis and improves the anti-tumor effect of Gemcitabine in PANC-1 cells.
