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Talampanel

CAS No. 161832-65-1

Talampanel( GYKI-53773 | LY-300164 )

Catalog No. M26835 CAS No. 161832-65-1

Talampanel is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 53 In Stock
2MG 30 In Stock
5MG 47 In Stock
10MG 70 In Stock
25MG 140 In Stock
50MG 230 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    Talampanel
  • Note
    Research use only, not for human use.
  • Brief Description
    Talampanel is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity.
  • Description
    Talampanel is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models.(In Vivo):Talampanel (p.o.; 5 mg/kg; once a day; 2 weeks) decreases motoneuronal calcium in a mouse model of ALS .
  • In Vitro
    ——
  • In Vivo
    Talampanel (orally administration; 5 mg/kg; once a day; 2 weeks) reduces motoneuronal calcium in a mouse model of ALS, but its efficacy declines as the disease progresses. Animal Model:Female mutant SOD1 Tg mice Dosage:5 mg/kg Administration:Orally administration; 5 mg/kg; once a day; 2 weeks Result:Had a significant effect in reducing the calcium level only at the age of 12 weeks.
  • Synonyms
    GYKI-53773 | LY-300164
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    ASK1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    161832-65-1
  • Formula Weight
    337.379
  • Molecular Formula
    C19H19N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (296.41 mM)
  • SMILES
    C[C@@H]1Cc2cc3OCOc3cc2C(=NN1C(C)=O)c1ccc(N)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kawarazaki Y, Ichijo H, Naguro I. Apoptosis signal-regulating kinase 1 as a therapeutic target. Expert Opin Ther Targets. 2014 Jun;18(6):651-64.
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