NS5806

Research use only, not for human use.

NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2.

NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM).(In Vitro):NS5806 activates canine transient outward potassium current (Ito) (IC50: 40.7 nM and an EC50 of 1.6 nM for inhibition and stimulation on the rabbit, respectively). NS5806 (10-100 nM) has concentration-dependent effects on ventricular and atrial Ito. NS5806 (10 μM) induces a 65% increase of KV4.3/KChIP2/DPP6 peak current amplitudes concentration-dependently and the time course of inactivation (τ) is slowed with an EC50 value of 25.4 μM in CHO-K1 cells.

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NS-5806

Cell Cycle/DNA Damage

Potassium Channel

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426834-69-7

574.079

C16H8Br2F6N6O

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (435.49 mM)

FC(F)(F)c1cc(NC(=O)Nc2c(Br)cc(Br)cc2-c2nn[nH]n2)cc(c1)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years