Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - Potassium Channel - DMP 543

DMP 543

CAS No. 160588-45-4

DMP 543( XR-543 | XR 543 | DMP-543 )

Catalog No. M12308 CAS No. 160588-45-4

A potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
10MG 32 In Stock
25MG 65 In Stock
50MG 103 In Stock
100MG 167 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    DMP 543
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM.
  • Description
    A potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM; maintains the 5- to 10-fold potency differential over linopirdine in increasing extracellular hippocampal ACh levels in the rat with a minimum effective dose of 1 mg/kg.Alzheimer Disease Phase 2 Discontinued.
  • In Vitro
    DMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM.
  • In Vivo
    ——
  • Synonyms
    XR-543 | XR 543 | DMP-543
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    160588-45-4
  • Formula Weight
    412.44
  • Molecular Formula
    C26H18F2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (242.47 mM)
  • SMILES
    O=C1C2=C(C=CC=C2)C(CC3=CC(F)=NC=C3)(CC4=CC(F)=NC=C4)C5=CC=CC=C15
  • Chemical Name
    10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Earl RA, et al. J Med Chem. 1998 Nov 5;41(23):4615-22. 2. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30. 3. Pesti JA, et al. J Org Chem. 2000 Nov 17;65(23):7718-22. 4. Ipavec V, et al. Pharmacol Res. 2011 Oct;64(4):397-409.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Repaglinide

    Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).

  • Apamin

    Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity. Apamin is a bee venom component and is strongly basic in nature.

  • Nateglinide

    Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).

Sign In Join Free