Cart
sales@molnova.com
DMP 543
CAS No. 160588-45-4
DMP 543( XR-543 | XR 543 | DMP-543 )
Catalog No. M12308 CAS No. 160588-45-4
A potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 58 | Get Quote |
|
| 10MG | 87 | Get Quote |
|
| 25MG | 205 | Get Quote |
|
| 50MG | 335 | Get Quote |
|
| 100MG | 500 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameDMP 543
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM.
-
DescriptionA potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM; maintains the 5- to 10-fold potency differential over linopirdine in increasing extracellular hippocampal ACh levels in the rat with a minimum effective dose of 1 mg/kg.Alzheimer Disease Phase 2 Discontinued.
-
In VitroDMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM.
-
In Vivo——
-
SynonymsXR-543 | XR 543 | DMP-543
-
PathwayCell Cycle/DNA Damage
-
TargetPotassium Channel
-
RecptorPotassium Channel
-
Research AreaNeurological Disease
-
IndicationAlzheimer Disease
Chemical Information
-
CAS Number160588-45-4
-
Formula Weight412.44
-
Molecular FormulaC26H18F2N2O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (242.47 mM)
-
SMILESO=C1C2=C(C=CC=C2)C(CC3=CC(F)=NC=C3)(CC4=CC(F)=NC=C4)C5=CC=CC=C15
-
Chemical Name10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Earl RA, et al. J Med Chem. 1998 Nov 5;41(23):4615-22.
2. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
3. Pesti JA, et al. J Org Chem. 2000 Nov 17;65(23):7718-22.
4. Ipavec V, et al. Pharmacol Res. 2011 Oct;64(4):397-409.
molnova catalog
related products
-
VU590
VU590 is a potent and moderately selective inhibitor of extrarenal medullary potassium ROMK (Kir1.1) that also inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling.
-
Pinacidil
Pinardil (P-1134, S-1230) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure and peripheral resistance and producing fluid retention.
-
Kv2-IN-A1
Kv2-IN-A1 is an inhibitor of Kv2.1 and Kv2.2.
