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AUT1

CAS No. 1311136-84-1

AUT1( —— )

Catalog No. M19956 CAS No. 1311136-84-1

AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AUT1
  • Note
    Research use only, not for human use.
  • Brief Description
    AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).
  • Description
    AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).
  • In Vitro
    AUT1 (1.5, 12.5, and 25 μM) modulates Kv3.1b and Kv3.2a channels in human recombinant with pEC50s of 5.33 and 5.31 μM, respectively.AUT1 increases whole currents mediated by human Kv3.1b and Kv3.2a channels in a concentration-dependent manner. AUT1 (10 and 30 μM) shifts both the voltage dependence of activation and inactivation of human Kv3.1b and Kv3.2a channels.AUT1 rescues (1 and 10 μM) the fast firing of EGFP-positive cortical interneurons.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Kv3.1b channels| Kv3.2a channels
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1311136-84-1
  • Formula Weight
    341.37
  • Molecular Formula
    C18H19N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 250 mg/mL (732.36 mM)
  • SMILES
    CC[C@H]1NC(=O)N(C1=O)c1ccc(Oc2ccc(C)c(OC)c2)nc1
  • Chemical Name
    (5R)-5-Ethyl-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-24-imidazolidinedione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Rosato-Siri MD et al. A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons. J Pharmacol Exp Ther. 2015 Sep;354(3):251-60.
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