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GPR120 Agonist 3
CAS No. 1599477-75-4
GPR120 Agonist 3( —— )
Catalog No. M26700 CAS No. 1599477-75-4
GPR120-IN-1 is a selective agonist of Gpr120 ( logEC50: -7.62).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 5MG | 77 | In Stock |
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| 10MG | 140 | In Stock |
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| 25MG | 275 | In Stock |
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| 50MG | 384 | In Stock |
|
| 100MG | 576 | In Stock |
|
| 200MG | 816 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGPR120 Agonist 3
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NoteResearch use only, not for human use.
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Brief DescriptionGPR120-IN-1 is a selective agonist of Gpr120 ( logEC50: -7.62).
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DescriptionGPR120-IN-1 is a selective agonist of Gpr120 ( logEC50: -7.62).(In Vitro):GPR120-IN-1 causes a concentration-dependent response to recruit β-arrestin-2 in both human and mouse Gpr120 expressing cells(EC50s : ~0.35 μM). GPR120-IN-1 produces concentration dependent increases in IP3 production from both human and mouse Gpr120 expressing cells. GPR120-IN-1 strongly and comparably inhibits LPS-induced phosphorylation of Ikkβ, Tak1, and Jnk and blocked IκB degradation. GPR120-IN-1 is fully selective for Gpr120 (logEC50= 7.62) with negligible activity towards Gpr40. (In Vivo):GPR120-IN-1 treatment has beneficial effects on hepatic lipid metabolism. Which causing decreased liver triglycerides, decreased hepatic steatosis, and DAGs, as well as decreased saturated free fatty acid conten. GPR120-IN-1 causes improved insulin sensitivity with increased glucose infusion rates. It also enhanced insulin stimulated-glucose disposal rate. Only in WT mice, along with a marked increase in the ability of insulin to suppress hepatic glucose production.
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In VitroGPR120 Agonist 3 is fully selective for Gpr120 (logEC50=?7.62) with negligible activity towards Gpr40. GPR120 Agonist 3 produces concentration dependent increases in IP3 production from both human and mouse Gpr120 expressing cells. GPR120 Agonist 3 leads to a concentration-dependent response to recruit β-arrestin-2 in both human and mouse Gpr120 expressing cells, with EC50s of ~0.35 μM. GPR120 Agonist 3 strongly and comparably inhibits LPS-induced phosphorylation of Tak1, Ikkβ, and Jnk and blocked IκB degradation .
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In VivoGPR120 Agonist 3 causes improved insulin sensitivity with increased glucose infusion rates, enhanced insulin stimulated-glucose disposal rate, along with a marked increase in the ability of insulin to suppress hepatic glucose production only in WT mice. GPR120 Agonist 3 treatment has beneficial effects on hepatic lipid metabolism, causing decreased hepatic steatosis, decreased liver triglycerides, and DAGs, along with reduced saturated free fatty acid conten.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetGPR
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1599477-75-4
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Formula Weight405.84
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Molecular FormulaC19H23ClF3NO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 50 mg/mL (123.20 mM)
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SMILESOC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hong X, et al. In Vitro Glucuronidation of Wushanicaritin by Liver Microsomes, Intestine Microsomes and Expressed Human UDP-Glucuronosyltransferase Enzymes. Int J Mol Sci. 2017 Sep 19;18(9). pii: E1983.
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