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Fenobam

CAS No. 57653-26-6

Fenobam( —— )

Catalog No. M26686 CAS No. 57653-26-6

Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Fenobam
  • Note
    Research use only, not for human use.
  • Brief Description
    Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity.
  • Description
    Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity. Fenobam is a selective and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively).(In Vivo):Fenobam sulfate (30-60 mg/kg; p.o.) inhibited cocaine self-administration significantly .
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Long-Evans rats (250-300 g)Dosage:30-60 mg/kg Administration:P.o.Result:Inhibited self-administration
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    MAGL
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    57653-26-6
  • Formula Weight
    266.69
  • Molecular Formula
    C11H11ClN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (374.98 mM)
  • SMILES
    CN1CC(=O)N=C1NC(=O)Nc1cccc(Cl)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shuhei Ikeda, et al. Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2 H-benzo[ b][1,4]oxazin-6-yl Moiety. J Med Chem. 2021 Aug 12;64(15):11014-11044.
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