Fenobam

Research use only, not for human use.

Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity.

Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity. Fenobam is a selective and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively).(In Vivo):Fenobam sulfate (30-60 mg/kg; p.o.) inhibited cocaine self-administration significantly .

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Animal Model:Male Long-Evans rats (250-300 g)Dosage:30-60 mg/kg Administration:P.o.Result:Inhibited self-administration

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Neuroscience

GluR

MAGL

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57653-26-6

266.69

C11H11ClN4O2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (374.98 mM)

CN1CC(=O)N=C1NC(=O)Nc1cccc(Cl)c1

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(-20℃)

With Ice Pack

≥ 2 years