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NPS2390

CAS No. 226878-01-9

NPS2390( —— )

Catalog No. M21958 CAS No. 226878-01-9

NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 44 In Stock
5MG 33 In Stock
10MG 55 In Stock
25MG 107 In Stock
50MG 183 In Stock
100MG 300 In Stock
200MG 414 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    NPS2390
  • Note
    Research use only, not for human use.
  • Brief Description
    NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively).
  • Description
    NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively). Treatment of NPS2390 was conducive to inhibit the proliferation and reverse phenotypic modulation of PASMCs by regulating autophagy levels.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    mGluR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    226878-01-9
  • Formula Weight
    307.4
  • Molecular Formula
    C19H21N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 6.25 mg/mL (20.33 mM)
  • SMILES
    O=C(NC12CC3CC(CC(C3)C1)C2)c1cnc2ccccc2n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Peng X , Wei C , Li H Z , et al. NPS2390, a Selective Calcium-sensing Receptor Antagonist Controls the Phenotypic Modulation of Hypoxic Human Pulmonary Arterial Smooth Muscle Cells by Regulating Autophagy[J]. Journal of Translational Internal Medicine, 2019, 7(2):59-68.
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