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CMS-121
CAS No. 1353224-53-9
CMS-121( CMS121 )
Catalog No. M26656 CAS No. 1353224-53-9
CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 65 | In Stock |
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| 2MG | 35 | In Stock |
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| 5MG | 58 | In Stock |
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| 10MG | 90 | In Stock |
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| 25MG | 169 | In Stock |
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| 50MG | 247 | In Stock |
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| 100MG | 369 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCMS-121
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NoteResearch use only, not for human use.
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Brief DescriptionCMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor.
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DescriptionCMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activities.(In Vitro):CMS-121 can increase acetyl-CoA in cells. CMS-121 (1 μM; 4 hours; HT22 cells) treatment also increases the phosphorylation of ACC1 at serine 79.(In Vivo):CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism. CMS-121 (~20 mg/kg; p.o; daily; for 4 months; female SAMP8 mice) treatment decreases cognitive decline and metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice.
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In VitroCMS-121 (1 μM; 4 hours; HT22 cells) treatment increases the phosphorylation of ACC1 at serine 79. CMS-121 can increase acetyl-CoA in cells. Western Blot Analysis Cell Line:HT22 cells Concentration:1 μM Incubation Time:4 hours Result: Increases the phosphorylation of ACC1 at serine 79.
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In VivoCMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism. Animal Model:Female SAMP8 mice (9 months old)Dosage:~20 mg/kg/day Administration:Oral administration; daily; for 4 months Result:Reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain.
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SynonymsCMS121
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PathwayMetabolic Enzyme/Protease
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TargetACC
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RecptorCMV| Feline herpesvirus type-1(FHV-1)| HSV-1| Nucleoside Antimetabolite/Analog
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Research Area——
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Indication——
Chemical Information
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CAS Number1353224-53-9
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Formula Weight321.376
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Molecular FormulaC20H19NO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (155.58 mM)
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SMILESOc1ccc(cc1O)-c1cc(OC2CCCC2)c2ccccc2n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Maggs DJ, Clarke HE. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65(4):399-403.
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