ND-654( ND654 | ND 654 )

Catalog No. M11847 CAS No. 1434641-55-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

ND-654
Note

Research use only, not for human use.
Brief Description

ND-654 (ND654) is a novel potent, liver-specific acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 3/8 nM for human ACC1/ACC2, respectively.
Description

ND-654 (ND654) is a novel potent, liver-specific acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 3/8 nM for human ACC1/ACC2, respectively; inhibits HepG2 cell fatty acid synthesis with an EC50 of 14 nM, and reduces both rat hepatic malonyl-CoA and rat hepatic fatty acid synthesis with ED50 values of 0.34 mg/kg and 0.30 mg/kg at Cmax, respectively; mimics the effects of ACC phosphorylation inhibits hepatic DNL and the development of HCC, selectively targets the liver and inhibits HCC proliferation, improves survival of tumor-bearing rats when used alone and in combination with the multi-kinase inhibitor sorafenib.
In Vitro

——
In Vivo

——
Synonyms

ND654 | ND 654
Pathway

Metabolic Enzyme/Protease
Target

ACC
Recptor

ACC
Research Area

——
Indication

——

CAS Number

1434641-55-0
Formula Weight

583.656
Molecular Formula

C29H33N3O8S
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

2-(1-((R)-2-(((1s,4S)-4-hydroxycyclohexyl)oxy)-2-(2-methoxyphenyl)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoic acid

1. Lally JSV, et al. Cell Metab. 2019 Jan 8;29(1):174-182.e5.

Calculator

molnova catalog