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AZ7550 hydrochloride

CAS No. 2309762-40-9

AZ7550 hydrochloride( AZ7550 hydrochloride (1421373-99-0 free base) )

Catalog No. M26549 CAS No. 2309762-40-9

AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZ7550 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
  • Description
    AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).(In Vitro):AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM).
  • In Vitro
    AZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC50s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI50s of 19, 15, and 537 nM, respectively.
  • In Vivo
    ——
  • Synonyms
    AZ7550 hydrochloride (1421373-99-0 free base)
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    Bacterial| GABAA| Human Endogenous Metabolite| Virus Protease
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2309762-40-9
  • Formula Weight
    522.04
  • Molecular Formula
    C27H32ClN7O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 1.88 mg/mL (3.60 mM)
  • SMILES
    C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(C)CCNC)=O.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yang H, et al. α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors. Mol Pharmacol. 2016 Nov;90(5):530-539.
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