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Poziotinib
CAS No. 1092364-38-9
Poziotinib( HM781-36B | NOV120101 )
Catalog No. M10347 CAS No. 1092364-38-9
Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2/5.3 nM/23.5 nM for HER1/HER2/HER4.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
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| 5MG | 81 | In Stock |
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| 10MG | 105 | In Stock |
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| 25MG | 243 | In Stock |
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| 50MG | 372 | In Stock |
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| 100MG | 554 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePoziotinib
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NoteResearch use only, not for human use.
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Brief DescriptionPoziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2/5.3 nM/23.5 nM for HER1/HER2/HER4.
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DescriptionPoziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2/5.3 nM/23.5 nM for HER1/HER2/HER4; inhibits phosphorylation of HER family and downstream signaling molecules, and induced apoptosis and G1 arrest; exerts synergistic effects with chemotherapeutic agents.Breast Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsHM781-36B | NOV120101
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PathwayAngiogenesis
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TargetEGFR
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RecptorHER1|HER2|HER4
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number1092364-38-9
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Formula Weight491.3423
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Molecular FormulaC23H21Cl2FN4O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC=CC(N1CCC(OC2=CC3=C(NC4=CC=C(Cl)C(Cl)=C4F)N=CN=C3C=C2OC)CC1)=O
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Chemical Name2-Propen-1-one, 1-[4-[[4-[(3,4-dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nam HJ, et al. Cancer Lett. 2011 Mar 28;302(2):155-65.
2. Cha MY, et al. Int J Cancer. 2012 May 15;130(10):2445-54.
3. Kim HJ, et al. Anticancer Drugs. 2012 Mar;23(3):288-97.
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