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CK2/ERK8-IN-1
CAS No. 1085822-09-8
CK2/ERK8-IN-1( TMCB )
Catalog No. M26119 CAS No. 1085822-09-8
CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 μM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCK2/ERK8-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionCK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 μM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy.
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DescriptionCK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 μM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 μM, 11.9 μM, and 15.25 μM).(In Vitro):In Jurkat cells, CK2/ERK8-IN-1 (Compound K66; 0-50 μM; 24 hours) treatment displays cytotoxic activity.
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In VitroCK2/ERK8-IN-1 (Compound K66; 0-50 μM; 24 hours; Jurkat cells) treatment displays cytotoxic activity in Jurkat cells. Cell Viability Assay Cell Line:Jurkat cells Concentration:0-50 μM Incubation Time:24 hours Result:Inhibited cell growth in a dose-dependent manner.
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In Vivo——
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SynonymsTMCB
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PathwayMetabolic Enzyme/Protease
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TargetCasein Kinase
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RecptorRET
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Research Area——
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Indication——
Chemical Information
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CAS Number1085822-09-8
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Formula Weight534.82
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Molecular FormulaC11H9Br4N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 16.67 mg/mL (31.17 mM)
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SMILESO=C(O)CN1C2=C(Br)C(Br)=C(Br)C(Br)=C2N=C1N(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Alao JP, et al. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer. 2014 Nov 20;14:853.
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